MFF-COL4A3 Fusion FISH Probe
The MFF-COL4A3 Fusion FISH Probe is used to confirm a fusion of the MFF and COL4A3 genes. The fusion of the MFF and COL4A3 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MFF-COL4A3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MFF-COL4A3-20-RERE | 20 (40 μL) | 200 μL |
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| MFF-COL4A3-20-REOR | 20 (40 μL) | 200 μL |
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| MFF-COL4A3-20-REGO | 20 (40 μL) | 200 μL |
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| MFF-COL4A3-20-REGR | 20 (40 μL) | 200 μL |
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| MFF-COL4A3-20-REAQ | 20 (40 μL) | 200 μL |
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| MFF-COL4A3-20-ORRE | 20 (40 μL) | 200 μL |
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| MFF-COL4A3-20-OROR | 20 (40 μL) | 200 μL |
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| MFF-COL4A3-20-ORGO | 20 (40 μL) | 200 μL |
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| MFF-COL4A3-20-ORAQ | 20 (40 μL) | 200 μL |
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| MFF-COL4A3-20-GORE | 20 (40 μL) | 200 μL |
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| MFF-COL4A3-20-GOOR | 20 (40 μL) | 200 μL |
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| MFF-COL4A3-20-GOGO | 20 (40 μL) | 200 μL |
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| MFF-COL4A3-20-GOGR | 20 (40 μL) | 200 μL |
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| MFF-COL4A3-20-GOAQ | 20 (40 μL) | 200 μL |
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| MFF-COL4A3-20-GRRE | 20 (40 μL) | 200 μL |
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| MFF-COL4A3-20-GROR | 20 (40 μL) | 200 μL |
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| MFF-COL4A3-20-GRGO | 20 (40 μL) | 200 μL |
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| MFF-COL4A3-20-GRGR | 20 (40 μL) | 200 μL |
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| MFF-COL4A3-20-GRAQ | 20 (40 μL) | 200 μL |
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| MFF-COL4A3-20-AQRE | 20 (40 μL) | 200 μL |
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| MFF-COL4A3-20-AQOR | 20 (40 μL) | 200 μL |
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| MFF-COL4A3-20-AQGO | 20 (40 μL) | 200 μL |
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| MFF-COL4A3-20-AQGR | 20 (40 μL) | 200 μL |
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| MFF-COL4A3-20-AQAQ | 20 (40 μL) | 200 μL |
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COL4A3 Gene Summary
Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jun 2010]
Gene Name: Collagen Type IV Alpha 3 Chain
Chromosome: CHR2: 228029280 -228179508
Locus: 2q36.3
MFF Gene Summary
This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Gene Name: Mitochondrial Fission Factor
Chromosome: CHR2: 228192227 -228222549
Locus: 2q36.3
Gene Diseases
The MFF COL4A3 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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