MEX3D-TCF3 Fusion FISH Probe
The MEX3D-TCF3 Fusion FISH Probe is used to confirm a fusion of the MEX3D and TCF3 genes. The fusion of the MEX3D and TCF3 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MEX3D-TCF3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MEX3D-TCF3-20-RERE | 20 (40 μL) | 200 μL |
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| MEX3D-TCF3-20-REOR | 20 (40 μL) | 200 μL |
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| MEX3D-TCF3-20-REGO | 20 (40 μL) | 200 μL |
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| MEX3D-TCF3-20-REGR | 20 (40 μL) | 200 μL |
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| MEX3D-TCF3-20-REAQ | 20 (40 μL) | 200 μL |
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| MEX3D-TCF3-20-ORRE | 20 (40 μL) | 200 μL |
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| MEX3D-TCF3-20-OROR | 20 (40 μL) | 200 μL |
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| MEX3D-TCF3-20-ORGO | 20 (40 μL) | 200 μL |
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| MEX3D-TCF3-20-ORAQ | 20 (40 μL) | 200 μL |
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| MEX3D-TCF3-20-GORE | 20 (40 μL) | 200 μL |
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| MEX3D-TCF3-20-GOOR | 20 (40 μL) | 200 μL |
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| MEX3D-TCF3-20-GOGO | 20 (40 μL) | 200 μL |
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| MEX3D-TCF3-20-GOGR | 20 (40 μL) | 200 μL |
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| MEX3D-TCF3-20-GOAQ | 20 (40 μL) | 200 μL |
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| MEX3D-TCF3-20-GRRE | 20 (40 μL) | 200 μL |
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| MEX3D-TCF3-20-GROR | 20 (40 μL) | 200 μL |
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| MEX3D-TCF3-20-GRGO | 20 (40 μL) | 200 μL |
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| MEX3D-TCF3-20-GRGR | 20 (40 μL) | 200 μL |
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| MEX3D-TCF3-20-GRAQ | 20 (40 μL) | 200 μL |
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| MEX3D-TCF3-20-AQRE | 20 (40 μL) | 200 μL |
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| MEX3D-TCF3-20-AQOR | 20 (40 μL) | 200 μL |
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| MEX3D-TCF3-20-AQGO | 20 (40 μL) | 200 μL |
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| MEX3D-TCF3-20-AQGR | 20 (40 μL) | 200 μL |
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| MEX3D-TCF3-20-AQAQ | 20 (40 μL) | 200 μL |
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TCF3 Gene Summary
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]
Gene Name: Transcription Factor 3
Chromosome: CHR19: 1609288 -1652328
Locus: 19p13.3
MEX3D Gene Summary
The Mex-3 RNA Binding Family Member D (MEX3D) gene is located on chr19 :1554667-1568057 at 19p13.3.
Gene Name: Mex-3 RNA Binding Family Member D
Chromosome: CHR19: 1554667 -1568057
Locus: 19p13.3
Gene Diseases
The MEX3D TCF3 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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