METAP2-VEZT Fusion FISH Probe
The METAP2-VEZT Fusion FISH Probe is used to confirm a fusion of the METAP2 and VEZT genes. The fusion of the METAP2 and VEZT genes has been associated with Breast Invasive Carcinoma, and Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| METAP2-VEZT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| METAP2-VEZT-20-RERE | 20 (40 μL) | 200 μL |
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| METAP2-VEZT-20-REOR | 20 (40 μL) | 200 μL |
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| METAP2-VEZT-20-REGO | 20 (40 μL) | 200 μL |
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| METAP2-VEZT-20-REGR | 20 (40 μL) | 200 μL |
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| METAP2-VEZT-20-REAQ | 20 (40 μL) | 200 μL |
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| METAP2-VEZT-20-ORRE | 20 (40 μL) | 200 μL |
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| METAP2-VEZT-20-OROR | 20 (40 μL) | 200 μL |
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| METAP2-VEZT-20-ORGO | 20 (40 μL) | 200 μL |
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| METAP2-VEZT-20-ORAQ | 20 (40 μL) | 200 μL |
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| METAP2-VEZT-20-GORE | 20 (40 μL) | 200 μL |
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| METAP2-VEZT-20-GOOR | 20 (40 μL) | 200 μL |
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| METAP2-VEZT-20-GOGO | 20 (40 μL) | 200 μL |
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| METAP2-VEZT-20-GOGR | 20 (40 μL) | 200 μL |
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| METAP2-VEZT-20-GOAQ | 20 (40 μL) | 200 μL |
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| METAP2-VEZT-20-GRRE | 20 (40 μL) | 200 μL |
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| METAP2-VEZT-20-GROR | 20 (40 μL) | 200 μL |
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| METAP2-VEZT-20-GRGO | 20 (40 μL) | 200 μL |
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| METAP2-VEZT-20-GRGR | 20 (40 μL) | 200 μL |
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| METAP2-VEZT-20-GRAQ | 20 (40 μL) | 200 μL |
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| METAP2-VEZT-20-AQRE | 20 (40 μL) | 200 μL |
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| METAP2-VEZT-20-AQOR | 20 (40 μL) | 200 μL |
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| METAP2-VEZT-20-AQGO | 20 (40 μL) | 200 μL |
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| METAP2-VEZT-20-AQGR | 20 (40 μL) | 200 μL |
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| METAP2-VEZT-20-AQAQ | 20 (40 μL) | 200 μL |
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METAP2 Gene Summary
The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Gene Name: Methionyl Aminopeptidase 2
Chromosome: CHR12: 95867821 -95909613
Locus: 12q22
VEZT Gene Summary
This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
Gene Name: Vezatin, Adherens Junctions Transmembrane Protein
Chromosome: CHR12: 95611521 -95696566
Locus: 12q22
Gene Diseases
The METAP2 VEZT Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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