MET-CAV1 Fusion FISH Probe
The MET-CAV1 Fusion FISH Probe is used to confirm a fusion of the MET and CAV1 genes. The fusion of the MET and CAV1 genes has been associated with Uterine Corpus Endometrial Carcinoma, Breast Invasive Carcinoma, and Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MET-CAV1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MET-CAV1-20-RERE | 20 (40 μL) | 200 μL |
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| MET-CAV1-20-REOR | 20 (40 μL) | 200 μL |
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| MET-CAV1-20-REGO | 20 (40 μL) | 200 μL |
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| MET-CAV1-20-REGR | 20 (40 μL) | 200 μL |
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| MET-CAV1-20-REAQ | 20 (40 μL) | 200 μL |
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| MET-CAV1-20-ORRE | 20 (40 μL) | 200 μL |
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| MET-CAV1-20-OROR | 20 (40 μL) | 200 μL |
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| MET-CAV1-20-ORGO | 20 (40 μL) | 200 μL |
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| MET-CAV1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MET-CAV1-20-GORE | 20 (40 μL) | 200 μL |
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| MET-CAV1-20-GOOR | 20 (40 μL) | 200 μL |
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| MET-CAV1-20-GOGO | 20 (40 μL) | 200 μL |
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| MET-CAV1-20-GOGR | 20 (40 μL) | 200 μL |
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| MET-CAV1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MET-CAV1-20-GRRE | 20 (40 μL) | 200 μL |
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| MET-CAV1-20-GROR | 20 (40 μL) | 200 μL |
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| MET-CAV1-20-GRGO | 20 (40 μL) | 200 μL |
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| MET-CAV1-20-GRGR | 20 (40 μL) | 200 μL |
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| MET-CAV1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MET-CAV1-20-AQRE | 20 (40 μL) | 200 μL |
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| MET-CAV1-20-AQOR | 20 (40 μL) | 200 μL |
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| MET-CAV1-20-AQGO | 20 (40 μL) | 200 μL |
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| MET-CAV1-20-AQGR | 20 (40 μL) | 200 μL |
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| MET-CAV1-20-AQAQ | 20 (40 μL) | 200 μL |
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CAV1 Gene Summary
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]
Gene Name: Caveolin 1
Chromosome: CHR7: 116164838 -116201239
Locus: 7q31.2
MET Gene Summary
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
Gene Name: MET Proto-oncogene, Receptor Tyrosine Kinase
Chromosome: CHR7: 116312458 -116438440
Locus: 7q31.2
Gene Diseases
The MET CAV1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
| Breast Invasive Carcinoma |
| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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