MEF2D-SORL1 Fusion FISH Probe
The MEF2D-SORL1 Fusion FISH Probe is used to confirm a fusion of the MEF2D and SORL1 genes. The fusion of the MEF2D and SORL1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MEF2D-SORL1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MEF2D-SORL1-20-RERE | 20 (40 μL) | 200 μL |
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| MEF2D-SORL1-20-REOR | 20 (40 μL) | 200 μL |
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| MEF2D-SORL1-20-REGO | 20 (40 μL) | 200 μL |
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| MEF2D-SORL1-20-REGR | 20 (40 μL) | 200 μL |
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| MEF2D-SORL1-20-REAQ | 20 (40 μL) | 200 μL |
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| MEF2D-SORL1-20-ORRE | 20 (40 μL) | 200 μL |
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| MEF2D-SORL1-20-OROR | 20 (40 μL) | 200 μL |
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| MEF2D-SORL1-20-ORGO | 20 (40 μL) | 200 μL |
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| MEF2D-SORL1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MEF2D-SORL1-20-GORE | 20 (40 μL) | 200 μL |
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| MEF2D-SORL1-20-GOOR | 20 (40 μL) | 200 μL |
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| MEF2D-SORL1-20-GOGO | 20 (40 μL) | 200 μL |
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| MEF2D-SORL1-20-GOGR | 20 (40 μL) | 200 μL |
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| MEF2D-SORL1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MEF2D-SORL1-20-GRRE | 20 (40 μL) | 200 μL |
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| MEF2D-SORL1-20-GROR | 20 (40 μL) | 200 μL |
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| MEF2D-SORL1-20-GRGO | 20 (40 μL) | 200 μL |
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| MEF2D-SORL1-20-GRGR | 20 (40 μL) | 200 μL |
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| MEF2D-SORL1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MEF2D-SORL1-20-AQRE | 20 (40 μL) | 200 μL |
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| MEF2D-SORL1-20-AQOR | 20 (40 μL) | 200 μL |
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| MEF2D-SORL1-20-AQGO | 20 (40 μL) | 200 μL |
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| MEF2D-SORL1-20-AQGR | 20 (40 μL) | 200 μL |
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| MEF2D-SORL1-20-AQAQ | 20 (40 μL) | 200 μL |
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MEF2D Gene Summary
This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Gene Name: Myocyte Enhancer Factor 2D
Chromosome: CHR1: 156433518 -156470529
Locus: 1q22
SORL1 Gene Summary
This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting. Mutations in this gene may be associated with Alzheimer's disease. [provided by RefSeq, Feb 2016]
Gene Name: Sortilin Related Receptor 1
Chromosome: CHR11: 121322911 -121504471
Locus: 11q24.1
Gene Diseases
The MEF2D SORL1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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