MED27-TG Fusion FISH Probe
The MED27-TG Fusion FISH Probe is used to confirm a fusion of the MED27 and TG genes. The fusion of the MED27 and TG genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MED27-TG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MED27-TG-20-RERE | 20 (40 μL) | 200 μL |
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| MED27-TG-20-REOR | 20 (40 μL) | 200 μL |
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| MED27-TG-20-REGO | 20 (40 μL) | 200 μL |
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| MED27-TG-20-REGR | 20 (40 μL) | 200 μL |
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| MED27-TG-20-REAQ | 20 (40 μL) | 200 μL |
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| MED27-TG-20-ORRE | 20 (40 μL) | 200 μL |
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| MED27-TG-20-OROR | 20 (40 μL) | 200 μL |
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| MED27-TG-20-ORGO | 20 (40 μL) | 200 μL |
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| MED27-TG-20-ORAQ | 20 (40 μL) | 200 μL |
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| MED27-TG-20-GORE | 20 (40 μL) | 200 μL |
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| MED27-TG-20-GOOR | 20 (40 μL) | 200 μL |
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| MED27-TG-20-GOGO | 20 (40 μL) | 200 μL |
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| MED27-TG-20-GOGR | 20 (40 μL) | 200 μL |
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| MED27-TG-20-GOAQ | 20 (40 μL) | 200 μL |
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| MED27-TG-20-GRRE | 20 (40 μL) | 200 μL |
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| MED27-TG-20-GROR | 20 (40 μL) | 200 μL |
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| MED27-TG-20-GRGO | 20 (40 μL) | 200 μL |
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| MED27-TG-20-GRGR | 20 (40 μL) | 200 μL |
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| MED27-TG-20-GRAQ | 20 (40 μL) | 200 μL |
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| MED27-TG-20-AQRE | 20 (40 μL) | 200 μL |
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| MED27-TG-20-AQOR | 20 (40 μL) | 200 μL |
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| MED27-TG-20-AQGO | 20 (40 μL) | 200 μL |
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| MED27-TG-20-AQGR | 20 (40 μL) | 200 μL |
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| MED27-TG-20-AQAQ | 20 (40 μL) | 200 μL |
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TG Gene Summary
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
Gene Name: Thyroglobulin
Chromosome: CHR8: 133879204 -134147143
Locus: 8q24.22
MED27 Gene Summary
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]
Gene Name: Mediator Complex Subunit 27
Chromosome: CHR9: 134735498 -134955253
Locus: 9q34.13
Gene Diseases
The MED27 TG Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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