MED25-AP2A1 Fusion FISH Probe
The MED25-AP2A1 Fusion FISH Probe is used to confirm a fusion of the MED25 and AP2A1 genes. The fusion of the MED25 and AP2A1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MED25-AP2A1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MED25-AP2A1-20-RERE | 20 (40 μL) | 200 μL |
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| MED25-AP2A1-20-REOR | 20 (40 μL) | 200 μL |
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| MED25-AP2A1-20-REGO | 20 (40 μL) | 200 μL |
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| MED25-AP2A1-20-REGR | 20 (40 μL) | 200 μL |
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| MED25-AP2A1-20-REAQ | 20 (40 μL) | 200 μL |
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| MED25-AP2A1-20-ORRE | 20 (40 μL) | 200 μL |
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| MED25-AP2A1-20-OROR | 20 (40 μL) | 200 μL |
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| MED25-AP2A1-20-ORGO | 20 (40 μL) | 200 μL |
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| MED25-AP2A1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MED25-AP2A1-20-GORE | 20 (40 μL) | 200 μL |
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| MED25-AP2A1-20-GOOR | 20 (40 μL) | 200 μL |
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| MED25-AP2A1-20-GOGO | 20 (40 μL) | 200 μL |
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| MED25-AP2A1-20-GOGR | 20 (40 μL) | 200 μL |
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| MED25-AP2A1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MED25-AP2A1-20-GRRE | 20 (40 μL) | 200 μL |
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| MED25-AP2A1-20-GROR | 20 (40 μL) | 200 μL |
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| MED25-AP2A1-20-GRGO | 20 (40 μL) | 200 μL |
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| MED25-AP2A1-20-GRGR | 20 (40 μL) | 200 μL |
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| MED25-AP2A1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MED25-AP2A1-20-AQRE | 20 (40 μL) | 200 μL |
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| MED25-AP2A1-20-AQOR | 20 (40 μL) | 200 μL |
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| MED25-AP2A1-20-AQGO | 20 (40 μL) | 200 μL |
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| MED25-AP2A1-20-AQGR | 20 (40 μL) | 200 μL |
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| MED25-AP2A1-20-AQAQ | 20 (40 μL) | 200 μL |
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AP2A1 Gene Summary
This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Adaptor Related Protein Complex 2 Alpha 1 Subunit
Chromosome: CHR19: 50270179 -50310369
Locus: 19q13.33
MED25 Gene Summary
This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2. [provided by RefSeq, Apr 2010]
Gene Name: Mediator Complex Subunit 25
Chromosome: CHR19: 50321535 -50340237
Locus: 19q13.33
Gene Diseases
The MED25 AP2A1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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