MED15-GNB1L Fusion FISH Probe
The MED15-GNB1L Fusion FISH Probe is used to confirm a fusion of the MED15 and GNB1L genes. The fusion of the MED15 and GNB1L genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MED15-GNB1L-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MED15-GNB1L-20-RERE | 20 (40 μL) | 200 μL |
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| MED15-GNB1L-20-REOR | 20 (40 μL) | 200 μL |
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| MED15-GNB1L-20-REGO | 20 (40 μL) | 200 μL |
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| MED15-GNB1L-20-REGR | 20 (40 μL) | 200 μL |
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| MED15-GNB1L-20-REAQ | 20 (40 μL) | 200 μL |
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| MED15-GNB1L-20-ORRE | 20 (40 μL) | 200 μL |
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| MED15-GNB1L-20-OROR | 20 (40 μL) | 200 μL |
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| MED15-GNB1L-20-ORGO | 20 (40 μL) | 200 μL |
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| MED15-GNB1L-20-ORAQ | 20 (40 μL) | 200 μL |
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| MED15-GNB1L-20-GORE | 20 (40 μL) | 200 μL |
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| MED15-GNB1L-20-GOOR | 20 (40 μL) | 200 μL |
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| MED15-GNB1L-20-GOGO | 20 (40 μL) | 200 μL |
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| MED15-GNB1L-20-GOGR | 20 (40 μL) | 200 μL |
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| MED15-GNB1L-20-GOAQ | 20 (40 μL) | 200 μL |
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| MED15-GNB1L-20-GRRE | 20 (40 μL) | 200 μL |
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| MED15-GNB1L-20-GROR | 20 (40 μL) | 200 μL |
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| MED15-GNB1L-20-GRGO | 20 (40 μL) | 200 μL |
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| MED15-GNB1L-20-GRGR | 20 (40 μL) | 200 μL |
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| MED15-GNB1L-20-GRAQ | 20 (40 μL) | 200 μL |
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| MED15-GNB1L-20-AQRE | 20 (40 μL) | 200 μL |
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| MED15-GNB1L-20-AQOR | 20 (40 μL) | 200 μL |
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| MED15-GNB1L-20-AQGO | 20 (40 μL) | 200 μL |
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| MED15-GNB1L-20-AQGR | 20 (40 μL) | 200 μL |
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| MED15-GNB1L-20-AQAQ | 20 (40 μL) | 200 μL |
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MED15 Gene Summary
The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Gene Name: Mediator Complex Subunit 15
Chromosome: CHR22: 20861885 -20941919
Locus: 22q11.21
GNB1L Gene Summary
This gene encodes a G-protein beta-subunit-like polypeptide which is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 6 WD repeats and is highly expressed in the heart. The gene maps to the region on chromosome 22q11, which is deleted in DiGeorge syndrome, trisomic in derivative 22 syndrome and tetrasomic in cat-eye syndrome. Therefore, this gene may contribute to the etiology of those disorders. Transcripts from this gene share exons with some transcripts from the C22orf29 gene. [provided by RefSeq, Jul 2008]
Gene Name: G Protein Subunit Beta 1 Like
Chromosome: CHR22: 19775933 -19842462
Locus: 22q11.21
Gene Diseases
The MED15 GNB1L Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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