MED13-ITGA3 Fusion FISH Probe
The MED13-ITGA3 Fusion FISH Probe is used to confirm a fusion of the MED13 and ITGA3 genes. The fusion of the MED13 and ITGA3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MED13-ITGA3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| MED13-ITGA3-20-RERE | 20 (40 μL) | 200 μL |
|
|
| MED13-ITGA3-20-REOR | 20 (40 μL) | 200 μL |
|
|
| MED13-ITGA3-20-REGO | 20 (40 μL) | 200 μL |
|
|
| MED13-ITGA3-20-REGR | 20 (40 μL) | 200 μL |
|
|
| MED13-ITGA3-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| MED13-ITGA3-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| MED13-ITGA3-20-OROR | 20 (40 μL) | 200 μL |
|
|
| MED13-ITGA3-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| MED13-ITGA3-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| MED13-ITGA3-20-GORE | 20 (40 μL) | 200 μL |
|
|
| MED13-ITGA3-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| MED13-ITGA3-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| MED13-ITGA3-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| MED13-ITGA3-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| MED13-ITGA3-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| MED13-ITGA3-20-GROR | 20 (40 μL) | 200 μL |
|
|
| MED13-ITGA3-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| MED13-ITGA3-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| MED13-ITGA3-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| MED13-ITGA3-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| MED13-ITGA3-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| MED13-ITGA3-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| MED13-ITGA3-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| MED13-ITGA3-20-AQAQ | 20 (40 μL) | 200 μL |
|
ITGA3 Gene Summary
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]
Gene Name: Integrin Subunit Alpha 3
Chromosome: CHR17: 48133339 -48167849
Locus: 17q21.33
MED13 Gene Summary
This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. [provided by RefSeq, Jul 2008]
Gene Name: Mediator Complex Subunit 13
Chromosome: CHR17: 60019965 -60142643
Locus: 17q23.2
Gene Diseases
The MED13 ITGA3 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|