MED1-GSDMB Fusion FISH Probe
The MED1-GSDMB Fusion FISH Probe is used to confirm a fusion of the MED1 and GSDMB genes. The fusion of the MED1 and GSDMB genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MED1-GSDMB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MED1-GSDMB-20-RERE | 20 (40 μL) | 200 μL |
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| MED1-GSDMB-20-REOR | 20 (40 μL) | 200 μL |
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| MED1-GSDMB-20-REGO | 20 (40 μL) | 200 μL |
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| MED1-GSDMB-20-REGR | 20 (40 μL) | 200 μL |
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| MED1-GSDMB-20-REAQ | 20 (40 μL) | 200 μL |
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| MED1-GSDMB-20-ORRE | 20 (40 μL) | 200 μL |
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| MED1-GSDMB-20-OROR | 20 (40 μL) | 200 μL |
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| MED1-GSDMB-20-ORGO | 20 (40 μL) | 200 μL |
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| MED1-GSDMB-20-ORAQ | 20 (40 μL) | 200 μL |
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| MED1-GSDMB-20-GORE | 20 (40 μL) | 200 μL |
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| MED1-GSDMB-20-GOOR | 20 (40 μL) | 200 μL |
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| MED1-GSDMB-20-GOGO | 20 (40 μL) | 200 μL |
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| MED1-GSDMB-20-GOGR | 20 (40 μL) | 200 μL |
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| MED1-GSDMB-20-GOAQ | 20 (40 μL) | 200 μL |
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| MED1-GSDMB-20-GRRE | 20 (40 μL) | 200 μL |
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| MED1-GSDMB-20-GROR | 20 (40 μL) | 200 μL |
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| MED1-GSDMB-20-GRGO | 20 (40 μL) | 200 μL |
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| MED1-GSDMB-20-GRGR | 20 (40 μL) | 200 μL |
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| MED1-GSDMB-20-GRAQ | 20 (40 μL) | 200 μL |
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| MED1-GSDMB-20-AQRE | 20 (40 μL) | 200 μL |
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| MED1-GSDMB-20-AQOR | 20 (40 μL) | 200 μL |
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| MED1-GSDMB-20-AQGO | 20 (40 μL) | 200 μL |
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| MED1-GSDMB-20-AQGR | 20 (40 μL) | 200 μL |
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| MED1-GSDMB-20-AQAQ | 20 (40 μL) | 200 μL |
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MED1 Gene Summary
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]
Gene Name: Mediator Complex Subunit 1
Chromosome: CHR17: 37560537 -37607527
Locus: 17q12
GSDMB Gene Summary
This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Alternative splicing and the use of alternative promoters results in multiple transcript variants. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. [provided by RefSeq, Nov 2016]
Gene Name: Gasdermin B
Chromosome: CHR17: 38060847 -38074903
Locus: 17q21.1
Gene Diseases
The MED1 GSDMB Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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