MED1-GRB7 Fusion FISH Probe
The MED1-GRB7 Fusion FISH Probe is used to confirm a fusion of the MED1 and GRB7 genes. The fusion of the MED1 and GRB7 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MED1-GRB7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MED1-GRB7-20-RERE | 20 (40 μL) | 200 μL |
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| MED1-GRB7-20-REOR | 20 (40 μL) | 200 μL |
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| MED1-GRB7-20-REGO | 20 (40 μL) | 200 μL |
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| MED1-GRB7-20-REGR | 20 (40 μL) | 200 μL |
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| MED1-GRB7-20-REAQ | 20 (40 μL) | 200 μL |
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| MED1-GRB7-20-ORRE | 20 (40 μL) | 200 μL |
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| MED1-GRB7-20-OROR | 20 (40 μL) | 200 μL |
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| MED1-GRB7-20-ORGO | 20 (40 μL) | 200 μL |
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| MED1-GRB7-20-ORAQ | 20 (40 μL) | 200 μL |
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| MED1-GRB7-20-GORE | 20 (40 μL) | 200 μL |
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| MED1-GRB7-20-GOOR | 20 (40 μL) | 200 μL |
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| MED1-GRB7-20-GOGO | 20 (40 μL) | 200 μL |
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| MED1-GRB7-20-GOGR | 20 (40 μL) | 200 μL |
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| MED1-GRB7-20-GOAQ | 20 (40 μL) | 200 μL |
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| MED1-GRB7-20-GRRE | 20 (40 μL) | 200 μL |
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| MED1-GRB7-20-GROR | 20 (40 μL) | 200 μL |
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| MED1-GRB7-20-GRGO | 20 (40 μL) | 200 μL |
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| MED1-GRB7-20-GRGR | 20 (40 μL) | 200 μL |
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| MED1-GRB7-20-GRAQ | 20 (40 μL) | 200 μL |
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| MED1-GRB7-20-AQRE | 20 (40 μL) | 200 μL |
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| MED1-GRB7-20-AQOR | 20 (40 μL) | 200 μL |
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| MED1-GRB7-20-AQGO | 20 (40 μL) | 200 μL |
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| MED1-GRB7-20-AQGR | 20 (40 μL) | 200 μL |
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| MED1-GRB7-20-AQAQ | 20 (40 μL) | 200 μL |
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GRB7 Gene Summary
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Gene Name: Growth Factor Receptor Bound Protein 7
Chromosome: CHR17: 37894161 -37903538
Locus: 17q12
MED1 Gene Summary
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]
Gene Name: Mediator Complex Subunit 1
Chromosome: CHR17: 37560537 -37607527
Locus: 17q12
Gene Diseases
The MED1 GRB7 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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