MECP2-F8 Fusion FISH Probe
The MECP2-F8 Fusion FISH Probe is used to confirm a fusion of the MECP2 and F8 genes. The fusion of the MECP2 and F8 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MECP2-F8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MECP2-F8-20-RERE | 20 (40 μL) | 200 μL |
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| MECP2-F8-20-REOR | 20 (40 μL) | 200 μL |
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| MECP2-F8-20-REGO | 20 (40 μL) | 200 μL |
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| MECP2-F8-20-REGR | 20 (40 μL) | 200 μL |
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| MECP2-F8-20-REAQ | 20 (40 μL) | 200 μL |
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| MECP2-F8-20-ORRE | 20 (40 μL) | 200 μL |
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| MECP2-F8-20-OROR | 20 (40 μL) | 200 μL |
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| MECP2-F8-20-ORGO | 20 (40 μL) | 200 μL |
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| MECP2-F8-20-ORAQ | 20 (40 μL) | 200 μL |
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| MECP2-F8-20-GORE | 20 (40 μL) | 200 μL |
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| MECP2-F8-20-GOOR | 20 (40 μL) | 200 μL |
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| MECP2-F8-20-GOGO | 20 (40 μL) | 200 μL |
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| MECP2-F8-20-GOGR | 20 (40 μL) | 200 μL |
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| MECP2-F8-20-GOAQ | 20 (40 μL) | 200 μL |
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| MECP2-F8-20-GRRE | 20 (40 μL) | 200 μL |
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| MECP2-F8-20-GROR | 20 (40 μL) | 200 μL |
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| MECP2-F8-20-GRGO | 20 (40 μL) | 200 μL |
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| MECP2-F8-20-GRGR | 20 (40 μL) | 200 μL |
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| MECP2-F8-20-GRAQ | 20 (40 μL) | 200 μL |
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| MECP2-F8-20-AQRE | 20 (40 μL) | 200 μL |
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| MECP2-F8-20-AQOR | 20 (40 μL) | 200 μL |
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| MECP2-F8-20-AQGO | 20 (40 μL) | 200 μL |
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| MECP2-F8-20-AQGR | 20 (40 μL) | 200 μL |
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| MECP2-F8-20-AQAQ | 20 (40 μL) | 200 μL |
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F8 Gene Summary
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]
Gene Name: Coagulation Factor VIII
Chromosome: CHRX: 154064063 -154250998
Locus: Xq28
MECP2 Gene Summary
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]
Gene Name: Methyl-CpG Binding Protein 2
Chromosome: CHRX: 153287263 -153363188
Locus: Xq28
Gene Diseases
The MECP2 F8 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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