MECOM-LMAN2L Fusion FISH Probe
The MECOM-LMAN2L Fusion FISH Probe is used to confirm a fusion of the MECOM and LMAN2L genes. The fusion of the MECOM and LMAN2L genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MECOM-LMAN2L-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| MECOM-LMAN2L-20-RERE | 20 (40 μL) | 200 μL |
|
|
| MECOM-LMAN2L-20-REOR | 20 (40 μL) | 200 μL |
|
|
| MECOM-LMAN2L-20-REGO | 20 (40 μL) | 200 μL |
|
|
| MECOM-LMAN2L-20-REGR | 20 (40 μL) | 200 μL |
|
|
| MECOM-LMAN2L-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| MECOM-LMAN2L-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| MECOM-LMAN2L-20-OROR | 20 (40 μL) | 200 μL |
|
|
| MECOM-LMAN2L-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| MECOM-LMAN2L-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| MECOM-LMAN2L-20-GORE | 20 (40 μL) | 200 μL |
|
|
| MECOM-LMAN2L-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| MECOM-LMAN2L-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| MECOM-LMAN2L-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| MECOM-LMAN2L-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| MECOM-LMAN2L-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| MECOM-LMAN2L-20-GROR | 20 (40 μL) | 200 μL |
|
|
| MECOM-LMAN2L-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| MECOM-LMAN2L-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| MECOM-LMAN2L-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| MECOM-LMAN2L-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| MECOM-LMAN2L-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| MECOM-LMAN2L-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| MECOM-LMAN2L-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| MECOM-LMAN2L-20-AQAQ | 20 (40 μL) | 200 μL |
|
MECOM Gene Summary
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Name: MDS1 And EVI1 Complex Locus
Chromosome: CHR3: 168801286 -169381563
Locus: 3q26.2
LMAN2L Gene Summary
This gene encodes a protein belonging to the L-type lectin group of type 1 membrane proteins, which function in the mammalian early secretory pathway. These proteins contain luminal carbohydrate recognition domains, which display homology to leguminous lectins. Unlike other proteins of the group, which cycle in the early secretory pathway and are predominantly associated with post endoplasmic reticulum membranes, the protein encoded by this gene is a non-cycling resident protein of the ER, where it functions as a cargo receptor for glycoproteins. It is proposed to regulate exchange of folded proteins for transport to the Golgi and exchange of misfolded glycoproteins for transport to the ubiquitin-proteasome pathway. [provided by RefSeq, Apr 2016]
Gene Name: Lectin, Mannose Binding 2 Like
Chromosome: CHR2: 97371666 -97405813
Locus: 2q11.2
Gene Diseases
The MECOM LMAN2L Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|