MECOM-CD86 Fusion FISH Probe
The MECOM-CD86 Fusion FISH Probe is used to confirm a fusion of the MECOM and CD86 genes. The fusion of the MECOM and CD86 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MECOM-CD86-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MECOM-CD86-20-RERE | 20 (40 μL) | 200 μL |
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| MECOM-CD86-20-REOR | 20 (40 μL) | 200 μL |
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| MECOM-CD86-20-REGO | 20 (40 μL) | 200 μL |
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| MECOM-CD86-20-REGR | 20 (40 μL) | 200 μL |
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| MECOM-CD86-20-REAQ | 20 (40 μL) | 200 μL |
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| MECOM-CD86-20-ORRE | 20 (40 μL) | 200 μL |
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| MECOM-CD86-20-OROR | 20 (40 μL) | 200 μL |
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| MECOM-CD86-20-ORGO | 20 (40 μL) | 200 μL |
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| MECOM-CD86-20-ORAQ | 20 (40 μL) | 200 μL |
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| MECOM-CD86-20-GORE | 20 (40 μL) | 200 μL |
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| MECOM-CD86-20-GOOR | 20 (40 μL) | 200 μL |
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| MECOM-CD86-20-GOGO | 20 (40 μL) | 200 μL |
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| MECOM-CD86-20-GOGR | 20 (40 μL) | 200 μL |
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| MECOM-CD86-20-GOAQ | 20 (40 μL) | 200 μL |
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| MECOM-CD86-20-GRRE | 20 (40 μL) | 200 μL |
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| MECOM-CD86-20-GROR | 20 (40 μL) | 200 μL |
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| MECOM-CD86-20-GRGO | 20 (40 μL) | 200 μL |
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| MECOM-CD86-20-GRGR | 20 (40 μL) | 200 μL |
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| MECOM-CD86-20-GRAQ | 20 (40 μL) | 200 μL |
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| MECOM-CD86-20-AQRE | 20 (40 μL) | 200 μL |
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| MECOM-CD86-20-AQOR | 20 (40 μL) | 200 μL |
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| MECOM-CD86-20-AQGO | 20 (40 μL) | 200 μL |
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| MECOM-CD86-20-AQGR | 20 (40 μL) | 200 μL |
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| MECOM-CD86-20-AQAQ | 20 (40 μL) | 200 μL |
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CD86 Gene Summary
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
Gene Name: CD86 Molecule
Chromosome: CHR3: 121774208 -121839988
Locus: 3q13.33
MECOM Gene Summary
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Name: MDS1 And EVI1 Complex Locus
Chromosome: CHR3: 168801286 -169381563
Locus: 3q26.2
Gene Diseases
The MECOM CD86 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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