MDM2-PTPRR Fusion FISH Probe
The MDM2-PTPRR Fusion FISH Probe is used to confirm a fusion of the MDM2 and PTPRR genes. The fusion of the MDM2 and PTPRR genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MDM2-PTPRR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MDM2-PTPRR-20-RERE | 20 (40 μL) | 200 μL |
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| MDM2-PTPRR-20-REOR | 20 (40 μL) | 200 μL |
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| MDM2-PTPRR-20-REGO | 20 (40 μL) | 200 μL |
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| MDM2-PTPRR-20-REGR | 20 (40 μL) | 200 μL |
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| MDM2-PTPRR-20-REAQ | 20 (40 μL) | 200 μL |
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| MDM2-PTPRR-20-ORRE | 20 (40 μL) | 200 μL |
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| MDM2-PTPRR-20-OROR | 20 (40 μL) | 200 μL |
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| MDM2-PTPRR-20-ORGO | 20 (40 μL) | 200 μL |
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| MDM2-PTPRR-20-ORAQ | 20 (40 μL) | 200 μL |
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| MDM2-PTPRR-20-GORE | 20 (40 μL) | 200 μL |
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| MDM2-PTPRR-20-GOOR | 20 (40 μL) | 200 μL |
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| MDM2-PTPRR-20-GOGO | 20 (40 μL) | 200 μL |
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| MDM2-PTPRR-20-GOGR | 20 (40 μL) | 200 μL |
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| MDM2-PTPRR-20-GOAQ | 20 (40 μL) | 200 μL |
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| MDM2-PTPRR-20-GRRE | 20 (40 μL) | 200 μL |
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| MDM2-PTPRR-20-GROR | 20 (40 μL) | 200 μL |
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| MDM2-PTPRR-20-GRGO | 20 (40 μL) | 200 μL |
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| MDM2-PTPRR-20-GRGR | 20 (40 μL) | 200 μL |
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| MDM2-PTPRR-20-GRAQ | 20 (40 μL) | 200 μL |
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| MDM2-PTPRR-20-AQRE | 20 (40 μL) | 200 μL |
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| MDM2-PTPRR-20-AQOR | 20 (40 μL) | 200 μL |
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| MDM2-PTPRR-20-AQGO | 20 (40 μL) | 200 μL |
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| MDM2-PTPRR-20-AQGR | 20 (40 μL) | 200 μL |
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| MDM2-PTPRR-20-AQAQ | 20 (40 μL) | 200 μL |
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MDM2 Gene Summary
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
Gene Name: MDM2 Proto-oncogene
Chromosome: CHR12: 69201970 -69239212
Locus: 12q15
PTPRR Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type R
Chromosome: CHR12: 71031852 -71314584
Locus: 12q15
Gene Diseases
The MDM2 PTPRR Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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