MDM2-NUP107 Fusion FISH Probe
The MDM2-NUP107 Fusion FISH Probe is used to confirm a fusion of the MDM2 and NUP107 genes. The fusion of the MDM2 and NUP107 genes has been associated with Breast Invasive Carcinoma, Lung Adenocarcinoma, and Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MDM2-NUP107-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MDM2-NUP107-20-RERE | 20 (40 μL) | 200 μL |
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| MDM2-NUP107-20-REOR | 20 (40 μL) | 200 μL |
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| MDM2-NUP107-20-REGO | 20 (40 μL) | 200 μL |
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| MDM2-NUP107-20-REGR | 20 (40 μL) | 200 μL |
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| MDM2-NUP107-20-REAQ | 20 (40 μL) | 200 μL |
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| MDM2-NUP107-20-ORRE | 20 (40 μL) | 200 μL |
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| MDM2-NUP107-20-OROR | 20 (40 μL) | 200 μL |
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| MDM2-NUP107-20-ORGO | 20 (40 μL) | 200 μL |
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| MDM2-NUP107-20-ORAQ | 20 (40 μL) | 200 μL |
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| MDM2-NUP107-20-GORE | 20 (40 μL) | 200 μL |
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| MDM2-NUP107-20-GOOR | 20 (40 μL) | 200 μL |
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| MDM2-NUP107-20-GOGO | 20 (40 μL) | 200 μL |
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| MDM2-NUP107-20-GOGR | 20 (40 μL) | 200 μL |
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| MDM2-NUP107-20-GOAQ | 20 (40 μL) | 200 μL |
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| MDM2-NUP107-20-GRRE | 20 (40 μL) | 200 μL |
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| MDM2-NUP107-20-GROR | 20 (40 μL) | 200 μL |
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| MDM2-NUP107-20-GRGO | 20 (40 μL) | 200 μL |
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| MDM2-NUP107-20-GRGR | 20 (40 μL) | 200 μL |
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| MDM2-NUP107-20-GRAQ | 20 (40 μL) | 200 μL |
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| MDM2-NUP107-20-AQRE | 20 (40 μL) | 200 μL |
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| MDM2-NUP107-20-AQOR | 20 (40 μL) | 200 μL |
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| MDM2-NUP107-20-AQGO | 20 (40 μL) | 200 μL |
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| MDM2-NUP107-20-AQGR | 20 (40 μL) | 200 μL |
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| MDM2-NUP107-20-AQAQ | 20 (40 μL) | 200 μL |
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MDM2 Gene Summary
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
Gene Name: MDM2 Proto-oncogene
Chromosome: CHR12: 69201970 -69239212
Locus: 12q15
NUP107 Gene Summary
This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Name: Nucleoporin 107
Chromosome: CHR12: 69080730 -69136473
Locus: 12q15
Gene Diseases
The MDM2 NUP107 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Lung Adenocarcinoma |
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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