MDM2-FGF18 Fusion FISH Probe
The MDM2-FGF18 Fusion FISH Probe is used to confirm a fusion of the MDM2 and FGF18 genes. The fusion of the MDM2 and FGF18 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MDM2-FGF18-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MDM2-FGF18-20-RERE | 20 (40 μL) | 200 μL |
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| MDM2-FGF18-20-REOR | 20 (40 μL) | 200 μL |
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| MDM2-FGF18-20-REGO | 20 (40 μL) | 200 μL |
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| MDM2-FGF18-20-REGR | 20 (40 μL) | 200 μL |
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| MDM2-FGF18-20-REAQ | 20 (40 μL) | 200 μL |
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| MDM2-FGF18-20-ORRE | 20 (40 μL) | 200 μL |
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| MDM2-FGF18-20-OROR | 20 (40 μL) | 200 μL |
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| MDM2-FGF18-20-ORGO | 20 (40 μL) | 200 μL |
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| MDM2-FGF18-20-ORAQ | 20 (40 μL) | 200 μL |
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| MDM2-FGF18-20-GORE | 20 (40 μL) | 200 μL |
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| MDM2-FGF18-20-GOOR | 20 (40 μL) | 200 μL |
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| MDM2-FGF18-20-GOGO | 20 (40 μL) | 200 μL |
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| MDM2-FGF18-20-GOGR | 20 (40 μL) | 200 μL |
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| MDM2-FGF18-20-GOAQ | 20 (40 μL) | 200 μL |
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| MDM2-FGF18-20-GRRE | 20 (40 μL) | 200 μL |
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| MDM2-FGF18-20-GROR | 20 (40 μL) | 200 μL |
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| MDM2-FGF18-20-GRGO | 20 (40 μL) | 200 μL |
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| MDM2-FGF18-20-GRGR | 20 (40 μL) | 200 μL |
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| MDM2-FGF18-20-GRAQ | 20 (40 μL) | 200 μL |
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| MDM2-FGF18-20-AQRE | 20 (40 μL) | 200 μL |
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| MDM2-FGF18-20-AQOR | 20 (40 μL) | 200 μL |
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| MDM2-FGF18-20-AQGO | 20 (40 μL) | 200 μL |
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| MDM2-FGF18-20-AQGR | 20 (40 μL) | 200 μL |
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| MDM2-FGF18-20-AQAQ | 20 (40 μL) | 200 μL |
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MDM2 Gene Summary
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
Gene Name: MDM2 Proto-oncogene
Chromosome: CHR12: 69201970 -69239212
Locus: 12q15
FGF18 Gene Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]
Gene Name: Fibroblast Growth Factor 18
Chromosome: CHR5: 170846666 -170884630
Locus: 5q35.1
Gene Diseases
The MDM2 FGF18 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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