MDM2-EGFR Fusion FISH Probe
The MDM2-EGFR Fusion FISH Probe is used to confirm a fusion of the MDM2 and EGFR genes. The fusion of the MDM2 and EGFR genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MDM2-EGFR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MDM2-EGFR-20-RERE | 20 (40 μL) | 200 μL |
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| MDM2-EGFR-20-REOR | 20 (40 μL) | 200 μL |
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| MDM2-EGFR-20-REGO | 20 (40 μL) | 200 μL |
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| MDM2-EGFR-20-REGR | 20 (40 μL) | 200 μL |
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| MDM2-EGFR-20-REAQ | 20 (40 μL) | 200 μL |
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| MDM2-EGFR-20-ORRE | 20 (40 μL) | 200 μL |
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| MDM2-EGFR-20-OROR | 20 (40 μL) | 200 μL |
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| MDM2-EGFR-20-ORGO | 20 (40 μL) | 200 μL |
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| MDM2-EGFR-20-ORAQ | 20 (40 μL) | 200 μL |
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| MDM2-EGFR-20-GORE | 20 (40 μL) | 200 μL |
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| MDM2-EGFR-20-GOOR | 20 (40 μL) | 200 μL |
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| MDM2-EGFR-20-GOGO | 20 (40 μL) | 200 μL |
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| MDM2-EGFR-20-GOGR | 20 (40 μL) | 200 μL |
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| MDM2-EGFR-20-GOAQ | 20 (40 μL) | 200 μL |
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| MDM2-EGFR-20-GRRE | 20 (40 μL) | 200 μL |
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| MDM2-EGFR-20-GROR | 20 (40 μL) | 200 μL |
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| MDM2-EGFR-20-GRGO | 20 (40 μL) | 200 μL |
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| MDM2-EGFR-20-GRGR | 20 (40 μL) | 200 μL |
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| MDM2-EGFR-20-GRAQ | 20 (40 μL) | 200 μL |
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| MDM2-EGFR-20-AQRE | 20 (40 μL) | 200 μL |
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| MDM2-EGFR-20-AQOR | 20 (40 μL) | 200 μL |
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| MDM2-EGFR-20-AQGO | 20 (40 μL) | 200 μL |
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| MDM2-EGFR-20-AQGR | 20 (40 μL) | 200 μL |
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| MDM2-EGFR-20-AQAQ | 20 (40 μL) | 200 μL |
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EGFR Gene Summary
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]
Gene Name: Epidermal Growth Factor Receptor
Chromosome: CHR7: 55086724 -55275031
Locus: 7p11.2
MDM2 Gene Summary
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
Gene Name: MDM2 Proto-oncogene
Chromosome: CHR12: 69201970 -69239212
Locus: 12q15
Gene Diseases
The MDM2 EGFR Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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