MDM2-DIP2B Fusion FISH Probe
The MDM2-DIP2B Fusion FISH Probe is used to confirm a fusion of the MDM2 and DIP2B genes. The fusion of the MDM2 and DIP2B genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MDM2-DIP2B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MDM2-DIP2B-20-RERE | 20 (40 μL) | 200 μL |
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| MDM2-DIP2B-20-REOR | 20 (40 μL) | 200 μL |
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| MDM2-DIP2B-20-REGO | 20 (40 μL) | 200 μL |
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| MDM2-DIP2B-20-REGR | 20 (40 μL) | 200 μL |
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| MDM2-DIP2B-20-REAQ | 20 (40 μL) | 200 μL |
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| MDM2-DIP2B-20-ORRE | 20 (40 μL) | 200 μL |
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| MDM2-DIP2B-20-OROR | 20 (40 μL) | 200 μL |
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| MDM2-DIP2B-20-ORGO | 20 (40 μL) | 200 μL |
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| MDM2-DIP2B-20-ORAQ | 20 (40 μL) | 200 μL |
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| MDM2-DIP2B-20-GORE | 20 (40 μL) | 200 μL |
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| MDM2-DIP2B-20-GOOR | 20 (40 μL) | 200 μL |
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| MDM2-DIP2B-20-GOGO | 20 (40 μL) | 200 μL |
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| MDM2-DIP2B-20-GOGR | 20 (40 μL) | 200 μL |
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| MDM2-DIP2B-20-GOAQ | 20 (40 μL) | 200 μL |
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| MDM2-DIP2B-20-GRRE | 20 (40 μL) | 200 μL |
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| MDM2-DIP2B-20-GROR | 20 (40 μL) | 200 μL |
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| MDM2-DIP2B-20-GRGO | 20 (40 μL) | 200 μL |
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| MDM2-DIP2B-20-GRGR | 20 (40 μL) | 200 μL |
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| MDM2-DIP2B-20-GRAQ | 20 (40 μL) | 200 μL |
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| MDM2-DIP2B-20-AQRE | 20 (40 μL) | 200 μL |
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| MDM2-DIP2B-20-AQOR | 20 (40 μL) | 200 μL |
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| MDM2-DIP2B-20-AQGO | 20 (40 μL) | 200 μL |
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| MDM2-DIP2B-20-AQGR | 20 (40 μL) | 200 μL |
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| MDM2-DIP2B-20-AQAQ | 20 (40 μL) | 200 μL |
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MDM2 Gene Summary
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
Gene Name: MDM2 Proto-oncogene
Chromosome: CHR12: 69201970 -69239212
Locus: 12q15
DIP2B Gene Summary
This gene encodes a member of the disco-interacting protein homolog 2 protein family. The encoded protein contains a binding site for the transcriptional regulator DNA methyltransferase 1 associated protein 1 as well as AMP-binding sites. The presence of these sites suggests that the encoded protein may participate in DNA methylation. This gene is located near a folate-sensitive fragile site, and CGG-repeat expansion in the promoter of this gene which affects transcription has been detected in individuals containing this fragile site on chromosome 12. [provided by RefSeq, Aug 2011]
Gene Name: Disco Interacting Protein 2 Homolog B
Chromosome: CHR12: 50898767 -51142450
Locus: 12q13.12
Gene Diseases
The MDM2 DIP2B Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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