MDM1-RBMS2 Fusion FISH Probe
The MDM1-RBMS2 Fusion FISH Probe is used to confirm a fusion of the MDM1 and RBMS2 genes. The fusion of the MDM1 and RBMS2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MDM1-RBMS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MDM1-RBMS2-20-RERE | 20 (40 μL) | 200 μL |
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| MDM1-RBMS2-20-REOR | 20 (40 μL) | 200 μL |
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| MDM1-RBMS2-20-REGO | 20 (40 μL) | 200 μL |
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| MDM1-RBMS2-20-REGR | 20 (40 μL) | 200 μL |
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| MDM1-RBMS2-20-REAQ | 20 (40 μL) | 200 μL |
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| MDM1-RBMS2-20-ORRE | 20 (40 μL) | 200 μL |
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| MDM1-RBMS2-20-OROR | 20 (40 μL) | 200 μL |
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| MDM1-RBMS2-20-ORGO | 20 (40 μL) | 200 μL |
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| MDM1-RBMS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| MDM1-RBMS2-20-GORE | 20 (40 μL) | 200 μL |
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| MDM1-RBMS2-20-GOOR | 20 (40 μL) | 200 μL |
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| MDM1-RBMS2-20-GOGO | 20 (40 μL) | 200 μL |
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| MDM1-RBMS2-20-GOGR | 20 (40 μL) | 200 μL |
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| MDM1-RBMS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| MDM1-RBMS2-20-GRRE | 20 (40 μL) | 200 μL |
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| MDM1-RBMS2-20-GROR | 20 (40 μL) | 200 μL |
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| MDM1-RBMS2-20-GRGO | 20 (40 μL) | 200 μL |
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| MDM1-RBMS2-20-GRGR | 20 (40 μL) | 200 μL |
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| MDM1-RBMS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| MDM1-RBMS2-20-AQRE | 20 (40 μL) | 200 μL |
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| MDM1-RBMS2-20-AQOR | 20 (40 μL) | 200 μL |
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| MDM1-RBMS2-20-AQGO | 20 (40 μL) | 200 μL |
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| MDM1-RBMS2-20-AQGR | 20 (40 μL) | 200 μL |
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| MDM1-RBMS2-20-AQAQ | 20 (40 μL) | 200 μL |
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RBMS2 Gene Summary
The protein encoded by this gene is a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. The RBMS proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. This protein was isolated by phenotypic complementation of cdc2 and cdc13 mutants of yeast and is thought to suppress cdc2 and cdc13 mutants through the induction of translation of cdc2. [provided by RefSeq, Jul 2008]
Gene Name: RNA Binding Motif Single Stranded Interacting Protein 2
Chromosome: CHR12: 56915608 -56989980
Locus: 12q13.3
MDM1 Gene Summary
This gene encodes a microtubule-binding nuclear protein that localizes to the centrioles of dividing cells and differentiating multiciliated cells, and negatively regulates centriole duplication. The encoded protein is closely associated with the centriole barrel, and resides in the centriole lumen. naturally occurring mutations in the orthologous mouse gene are associated with age-related retinal degeneration. [provided by RefSeq, Aug 2017]
Gene Name: Mdm1 Nuclear Protein
Chromosome: CHR12: 68688345 -68726161
Locus: 12q15
Gene Diseases
The MDM1 RBMS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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