MDH1-COMMD1 Fusion FISH Probe
The MDH1-COMMD1 Fusion FISH Probe is used to confirm a fusion of the MDH1 and COMMD1 genes. The fusion of the MDH1 and COMMD1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MDH1-COMMD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MDH1-COMMD1-20-RERE | 20 (40 μL) | 200 μL |
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| MDH1-COMMD1-20-REOR | 20 (40 μL) | 200 μL |
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| MDH1-COMMD1-20-REGO | 20 (40 μL) | 200 μL |
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| MDH1-COMMD1-20-REGR | 20 (40 μL) | 200 μL |
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| MDH1-COMMD1-20-REAQ | 20 (40 μL) | 200 μL |
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| MDH1-COMMD1-20-ORRE | 20 (40 μL) | 200 μL |
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| MDH1-COMMD1-20-OROR | 20 (40 μL) | 200 μL |
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| MDH1-COMMD1-20-ORGO | 20 (40 μL) | 200 μL |
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| MDH1-COMMD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MDH1-COMMD1-20-GORE | 20 (40 μL) | 200 μL |
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| MDH1-COMMD1-20-GOOR | 20 (40 μL) | 200 μL |
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| MDH1-COMMD1-20-GOGO | 20 (40 μL) | 200 μL |
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| MDH1-COMMD1-20-GOGR | 20 (40 μL) | 200 μL |
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| MDH1-COMMD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MDH1-COMMD1-20-GRRE | 20 (40 μL) | 200 μL |
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| MDH1-COMMD1-20-GROR | 20 (40 μL) | 200 μL |
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| MDH1-COMMD1-20-GRGO | 20 (40 μL) | 200 μL |
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| MDH1-COMMD1-20-GRGR | 20 (40 μL) | 200 μL |
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| MDH1-COMMD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MDH1-COMMD1-20-AQRE | 20 (40 μL) | 200 μL |
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| MDH1-COMMD1-20-AQOR | 20 (40 μL) | 200 μL |
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| MDH1-COMMD1-20-AQGO | 20 (40 μL) | 200 μL |
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| MDH1-COMMD1-20-AQGR | 20 (40 μL) | 200 μL |
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| MDH1-COMMD1-20-AQAQ | 20 (40 μL) | 200 μL |
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MDH1 Gene Summary
This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 6. [provided by RefSeq, Feb 2016]
Gene Name: Malate Dehydrogenase 1
Chromosome: CHR2: 63815742 -63834330
Locus: 2p15
COMMD1 Gene Summary
COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).[supplied by OMIM, Sep 2009]
Gene Name: Copper Metabolism Domain Containing 1
Chromosome: CHR2: 62132802 -62363205
Locus: 2p15
Gene Diseases
The MDH1 COMMD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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