MCOLN2-CDK1 Fusion FISH Probe
The MCOLN2-CDK1 Fusion FISH Probe is used to confirm a fusion of the MCOLN2 and CDK1 genes. The fusion of the MCOLN2 and CDK1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MCOLN2-CDK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MCOLN2-CDK1-20-RERE | 20 (40 μL) | 200 μL |
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| MCOLN2-CDK1-20-REOR | 20 (40 μL) | 200 μL |
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| MCOLN2-CDK1-20-REGO | 20 (40 μL) | 200 μL |
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| MCOLN2-CDK1-20-REGR | 20 (40 μL) | 200 μL |
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| MCOLN2-CDK1-20-REAQ | 20 (40 μL) | 200 μL |
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| MCOLN2-CDK1-20-ORRE | 20 (40 μL) | 200 μL |
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| MCOLN2-CDK1-20-OROR | 20 (40 μL) | 200 μL |
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| MCOLN2-CDK1-20-ORGO | 20 (40 μL) | 200 μL |
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| MCOLN2-CDK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MCOLN2-CDK1-20-GORE | 20 (40 μL) | 200 μL |
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| MCOLN2-CDK1-20-GOOR | 20 (40 μL) | 200 μL |
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| MCOLN2-CDK1-20-GOGO | 20 (40 μL) | 200 μL |
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| MCOLN2-CDK1-20-GOGR | 20 (40 μL) | 200 μL |
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| MCOLN2-CDK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MCOLN2-CDK1-20-GRRE | 20 (40 μL) | 200 μL |
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| MCOLN2-CDK1-20-GROR | 20 (40 μL) | 200 μL |
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| MCOLN2-CDK1-20-GRGO | 20 (40 μL) | 200 μL |
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| MCOLN2-CDK1-20-GRGR | 20 (40 μL) | 200 μL |
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| MCOLN2-CDK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MCOLN2-CDK1-20-AQRE | 20 (40 μL) | 200 μL |
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| MCOLN2-CDK1-20-AQOR | 20 (40 μL) | 200 μL |
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| MCOLN2-CDK1-20-AQGO | 20 (40 μL) | 200 μL |
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| MCOLN2-CDK1-20-AQGR | 20 (40 μL) | 200 μL |
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| MCOLN2-CDK1-20-AQAQ | 20 (40 μL) | 200 μL |
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CDK1 Gene Summary
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Name: Cyclin Dependent Kinase 1
Chromosome: CHR10: 62538211 -62554610
Locus: 10q21.2
MCOLN2 Gene Summary
Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]).[supplied by OMIM, Sep 2009]
Gene Name: Mucolipin 2
Chromosome: CHR1: 85391265 -85462796
Locus: 1p22.3
Gene Diseases
The MCOLN2 CDK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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