MCM5-HMOX1 Fusion FISH Probe
The MCM5-HMOX1 Fusion FISH Probe is used to confirm a fusion of the MCM5 and HMOX1 genes. The fusion of the MCM5 and HMOX1 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MCM5-HMOX1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MCM5-HMOX1-20-RERE | 20 (40 μL) | 200 μL |
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| MCM5-HMOX1-20-REOR | 20 (40 μL) | 200 μL |
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| MCM5-HMOX1-20-REGO | 20 (40 μL) | 200 μL |
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| MCM5-HMOX1-20-REGR | 20 (40 μL) | 200 μL |
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| MCM5-HMOX1-20-REAQ | 20 (40 μL) | 200 μL |
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| MCM5-HMOX1-20-ORRE | 20 (40 μL) | 200 μL |
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| MCM5-HMOX1-20-OROR | 20 (40 μL) | 200 μL |
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| MCM5-HMOX1-20-ORGO | 20 (40 μL) | 200 μL |
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| MCM5-HMOX1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MCM5-HMOX1-20-GORE | 20 (40 μL) | 200 μL |
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| MCM5-HMOX1-20-GOOR | 20 (40 μL) | 200 μL |
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| MCM5-HMOX1-20-GOGO | 20 (40 μL) | 200 μL |
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| MCM5-HMOX1-20-GOGR | 20 (40 μL) | 200 μL |
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| MCM5-HMOX1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MCM5-HMOX1-20-GRRE | 20 (40 μL) | 200 μL |
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| MCM5-HMOX1-20-GROR | 20 (40 μL) | 200 μL |
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| MCM5-HMOX1-20-GRGO | 20 (40 μL) | 200 μL |
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| MCM5-HMOX1-20-GRGR | 20 (40 μL) | 200 μL |
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| MCM5-HMOX1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MCM5-HMOX1-20-AQRE | 20 (40 μL) | 200 μL |
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| MCM5-HMOX1-20-AQOR | 20 (40 μL) | 200 μL |
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| MCM5-HMOX1-20-AQGO | 20 (40 μL) | 200 μL |
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| MCM5-HMOX1-20-AQGR | 20 (40 μL) | 200 μL |
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| MCM5-HMOX1-20-AQAQ | 20 (40 μL) | 200 μL |
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HMOX1 Gene Summary
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]
Gene Name: Heme Oxygenase 1
Chromosome: CHR22: 35777059 -35790207
Locus: 22q12.3
MCM5 Gene Summary
The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008]
Gene Name: Minichromosome Maintenance Complex Component 5
Chromosome: CHR22: 35796115 -35820495
Locus: 22q12.3
Gene Diseases
The MCM5 HMOX1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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