MCL1-AR Fusion FISH Probe
The MCL1-AR Fusion FISH Probe is used to confirm a fusion of the MCL1 and AR genes. The fusion of the MCL1 and AR genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MCL1-AR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MCL1-AR-20-RERE | 20 (40 μL) | 200 μL |
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| MCL1-AR-20-REOR | 20 (40 μL) | 200 μL |
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| MCL1-AR-20-REGO | 20 (40 μL) | 200 μL |
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| MCL1-AR-20-REGR | 20 (40 μL) | 200 μL |
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| MCL1-AR-20-REAQ | 20 (40 μL) | 200 μL |
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| MCL1-AR-20-ORRE | 20 (40 μL) | 200 μL |
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| MCL1-AR-20-OROR | 20 (40 μL) | 200 μL |
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| MCL1-AR-20-ORGO | 20 (40 μL) | 200 μL |
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| MCL1-AR-20-ORAQ | 20 (40 μL) | 200 μL |
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| MCL1-AR-20-GORE | 20 (40 μL) | 200 μL |
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| MCL1-AR-20-GOOR | 20 (40 μL) | 200 μL |
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| MCL1-AR-20-GOGO | 20 (40 μL) | 200 μL |
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| MCL1-AR-20-GOGR | 20 (40 μL) | 200 μL |
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| MCL1-AR-20-GOAQ | 20 (40 μL) | 200 μL |
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| MCL1-AR-20-GRRE | 20 (40 μL) | 200 μL |
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| MCL1-AR-20-GROR | 20 (40 μL) | 200 μL |
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| MCL1-AR-20-GRGO | 20 (40 μL) | 200 μL |
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| MCL1-AR-20-GRGR | 20 (40 μL) | 200 μL |
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| MCL1-AR-20-GRAQ | 20 (40 μL) | 200 μL |
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| MCL1-AR-20-AQRE | 20 (40 μL) | 200 μL |
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| MCL1-AR-20-AQOR | 20 (40 μL) | 200 μL |
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| MCL1-AR-20-AQGO | 20 (40 μL) | 200 μL |
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| MCL1-AR-20-AQGR | 20 (40 μL) | 200 μL |
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| MCL1-AR-20-AQAQ | 20 (40 μL) | 200 μL |
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AR Gene Summary
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
Gene Name: Androgen Receptor
Chromosome: CHRX: 66763873 -66944119
Locus: Xq12
MCL1 Gene Summary
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
Gene Name: MCL1, BCL2 Family Apoptosis Regulator
Chromosome: CHR1: 150547026 -150552214
Locus: 1q21.2
Gene Diseases
The MCL1 AR Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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