MCFD2-SRBD1 Fusion FISH Probe
The MCFD2-SRBD1 Fusion FISH Probe is used to confirm a fusion of the MCFD2 and SRBD1 genes. The fusion of the MCFD2 and SRBD1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MCFD2-SRBD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MCFD2-SRBD1-20-RERE | 20 (40 μL) | 200 μL |
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| MCFD2-SRBD1-20-REOR | 20 (40 μL) | 200 μL |
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| MCFD2-SRBD1-20-REGO | 20 (40 μL) | 200 μL |
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| MCFD2-SRBD1-20-REGR | 20 (40 μL) | 200 μL |
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| MCFD2-SRBD1-20-REAQ | 20 (40 μL) | 200 μL |
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| MCFD2-SRBD1-20-ORRE | 20 (40 μL) | 200 μL |
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| MCFD2-SRBD1-20-OROR | 20 (40 μL) | 200 μL |
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| MCFD2-SRBD1-20-ORGO | 20 (40 μL) | 200 μL |
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| MCFD2-SRBD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MCFD2-SRBD1-20-GORE | 20 (40 μL) | 200 μL |
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| MCFD2-SRBD1-20-GOOR | 20 (40 μL) | 200 μL |
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| MCFD2-SRBD1-20-GOGO | 20 (40 μL) | 200 μL |
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| MCFD2-SRBD1-20-GOGR | 20 (40 μL) | 200 μL |
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| MCFD2-SRBD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MCFD2-SRBD1-20-GRRE | 20 (40 μL) | 200 μL |
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| MCFD2-SRBD1-20-GROR | 20 (40 μL) | 200 μL |
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| MCFD2-SRBD1-20-GRGO | 20 (40 μL) | 200 μL |
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| MCFD2-SRBD1-20-GRGR | 20 (40 μL) | 200 μL |
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| MCFD2-SRBD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MCFD2-SRBD1-20-AQRE | 20 (40 μL) | 200 μL |
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| MCFD2-SRBD1-20-AQOR | 20 (40 μL) | 200 μL |
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| MCFD2-SRBD1-20-AQGO | 20 (40 μL) | 200 μL |
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| MCFD2-SRBD1-20-AQGR | 20 (40 μL) | 200 μL |
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| MCFD2-SRBD1-20-AQAQ | 20 (40 μL) | 200 μL |
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SRBD1 Gene Summary
The S1 RNA Binding Domain 1 (SRBD1) gene is located on chr2 :45615818-45838433 at 2p21.
Gene Name: S1 RNA Binding Domain 1
Chromosome: CHR2: 45615818 -45838433
Locus: 2p21
MCFD2 Gene Summary
This gene encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a complex with LMAN1 (lectin mannose binding protein 1; also known as ERGIC-53) that facilitates the transport of coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment (ERGIC). Mutations in this gene cause combined deficiency of FV and FVIII (F5F8D); a rare autosomal recessive bleeding disorder characterized by mild to moderate bleeding and coordinate reduction in plasma FV and FVIII levels. This protein has also been shown to maintain stem cell potential in adult central nervous system and is a marker for testicular germ cell tumors. The 3' UTR of this gene contains a transposon-like human repeat element named 'THE 1'. A processed RNA pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2016]
Gene Name: Multiple Coagulation Factor Deficiency 2
Chromosome: CHR2: 47129008 -47168994
Locus: 2p21
Gene Diseases
The MCFD2 SRBD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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