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MCF2L2-DMRT1 Fusion FISH Probe

The MCF2L2-DMRT1 Fusion FISH Probe is used to confirm a fusion of the MCF2L2 and DMRT1 genes. The fusion of the MCF2L2 and DMRT1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
MCF2L2-DMRT1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
MCF2L2-DMRT1-20-RERE 20 (40 μL) 200 μL
MCF2L2-DMRT1-20-REOR 20 (40 μL) 200 μL
MCF2L2-DMRT1-20-REGO 20 (40 μL) 200 μL
MCF2L2-DMRT1-20-REGR 20 (40 μL) 200 μL
MCF2L2-DMRT1-20-REAQ 20 (40 μL) 200 μL
MCF2L2-DMRT1-20-ORRE 20 (40 μL) 200 μL
MCF2L2-DMRT1-20-OROR 20 (40 μL) 200 μL
MCF2L2-DMRT1-20-ORGO 20 (40 μL) 200 μL
MCF2L2-DMRT1-20-ORAQ 20 (40 μL) 200 μL
MCF2L2-DMRT1-20-GORE 20 (40 μL) 200 μL
MCF2L2-DMRT1-20-GOOR 20 (40 μL) 200 μL
MCF2L2-DMRT1-20-GOGO 20 (40 μL) 200 μL
MCF2L2-DMRT1-20-GOGR 20 (40 μL) 200 μL
MCF2L2-DMRT1-20-GOAQ 20 (40 μL) 200 μL
MCF2L2-DMRT1-20-GRRE 20 (40 μL) 200 μL
MCF2L2-DMRT1-20-GROR 20 (40 μL) 200 μL
MCF2L2-DMRT1-20-GRGO 20 (40 μL) 200 μL
MCF2L2-DMRT1-20-GRGR 20 (40 μL) 200 μL
MCF2L2-DMRT1-20-GRAQ 20 (40 μL) 200 μL
MCF2L2-DMRT1-20-AQRE 20 (40 μL) 200 μL
MCF2L2-DMRT1-20-AQOR 20 (40 μL) 200 μL
MCF2L2-DMRT1-20-AQGO 20 (40 μL) 200 μL
MCF2L2-DMRT1-20-AQGR 20 (40 μL) 200 μL
MCF2L2-DMRT1-20-AQAQ 20 (40 μL) 200 μL

DMRT1 Gene Summary

This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. [provided by RefSeq, Jul 2008]

Gene Name: Doublesex And Mab-3 Related Transcription Factor 1

Chromosome: CHR9: 841689 -969090

Locus: 9p24.3

MCF2L2 Gene Summary

The MCF.2 Cell Line Derived Transforming Sequence-like 2 (MCF2L2) gene is located on chr3 :182895830-183145855 at 3q27.1.

Gene Name: MCF.2 Cell Line Derived Transforming Sequence-like 2

Chromosome: CHR3: 182895830 -183145855

Locus: 3q27.1

Gene Diseases

The MCF2L2 DMRT1 Fusion has been associated with the following diseases:

Disease Name
Skin Cutaneous Melanoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Loss of DMRT1 gene in a Mos 45,XY,-9[8]/46,XY,r(9)[29]/47,XY,+idic r(9)x2[1]/46,XY,idic r(9)[1]/46,XY[1] female presenting with short stature

A 46,XY sex reversal syndrome is characterized genetically by aberrations in chromosome 9pter due to involvement of the DMRT1 gene. A case study was under analysis to better understand the syndrome. FISH analysis was used with our DMRT1 gene probe. It was found that sex reversal can be due to haploinsufficiency of the DMRT1 gene in ring chromosome 9, although it is rare. This finding highlights the importance of the DMRT1 gene in sex determination.