MCCC2-NNT Fusion FISH Probe
The MCCC2-NNT Fusion FISH Probe is used to confirm a fusion of the MCCC2 and NNT genes. The fusion of the MCCC2 and NNT genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MCCC2-NNT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MCCC2-NNT-20-RERE | 20 (40 μL) | 200 μL |
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| MCCC2-NNT-20-REOR | 20 (40 μL) | 200 μL |
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| MCCC2-NNT-20-REGO | 20 (40 μL) | 200 μL |
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| MCCC2-NNT-20-REGR | 20 (40 μL) | 200 μL |
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| MCCC2-NNT-20-REAQ | 20 (40 μL) | 200 μL |
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| MCCC2-NNT-20-ORRE | 20 (40 μL) | 200 μL |
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| MCCC2-NNT-20-OROR | 20 (40 μL) | 200 μL |
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| MCCC2-NNT-20-ORGO | 20 (40 μL) | 200 μL |
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| MCCC2-NNT-20-ORAQ | 20 (40 μL) | 200 μL |
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| MCCC2-NNT-20-GORE | 20 (40 μL) | 200 μL |
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| MCCC2-NNT-20-GOOR | 20 (40 μL) | 200 μL |
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| MCCC2-NNT-20-GOGO | 20 (40 μL) | 200 μL |
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| MCCC2-NNT-20-GOGR | 20 (40 μL) | 200 μL |
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| MCCC2-NNT-20-GOAQ | 20 (40 μL) | 200 μL |
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| MCCC2-NNT-20-GRRE | 20 (40 μL) | 200 μL |
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| MCCC2-NNT-20-GROR | 20 (40 μL) | 200 μL |
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| MCCC2-NNT-20-GRGO | 20 (40 μL) | 200 μL |
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| MCCC2-NNT-20-GRGR | 20 (40 μL) | 200 μL |
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| MCCC2-NNT-20-GRAQ | 20 (40 μL) | 200 μL |
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| MCCC2-NNT-20-AQRE | 20 (40 μL) | 200 μL |
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| MCCC2-NNT-20-AQOR | 20 (40 μL) | 200 μL |
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| MCCC2-NNT-20-AQGO | 20 (40 μL) | 200 μL |
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| MCCC2-NNT-20-AQGR | 20 (40 μL) | 200 μL |
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| MCCC2-NNT-20-AQAQ | 20 (40 μL) | 200 μL |
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NNT Gene Summary
This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. [provided by RefSeq, Sep 2016]
Gene Name: Nicotinamide Nucleotide Transhydrogenase
Chromosome: CHR5: 43602790 -43705668
Locus: 5p12
MCCC2 Gene Summary
This gene encodes the small subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, an autosomal recessive disorder of leucine catabolism. [provided by RefSeq, Jul 2008]
Gene Name: Methylcrotonoyl-CoA Carboxylase 2
Chromosome: CHR5: 70883114 -70954530
Locus: 5q13.2
Gene Diseases
The MCCC2 NNT Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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