MCC-DBN1 Fusion FISH Probe
The MCC-DBN1 Fusion FISH Probe is used to confirm a fusion of the MCC and DBN1 genes. The fusion of the MCC and DBN1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MCC-DBN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MCC-DBN1-20-RERE | 20 (40 μL) | 200 μL |
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| MCC-DBN1-20-REOR | 20 (40 μL) | 200 μL |
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| MCC-DBN1-20-REGO | 20 (40 μL) | 200 μL |
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| MCC-DBN1-20-REGR | 20 (40 μL) | 200 μL |
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| MCC-DBN1-20-REAQ | 20 (40 μL) | 200 μL |
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| MCC-DBN1-20-ORRE | 20 (40 μL) | 200 μL |
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| MCC-DBN1-20-OROR | 20 (40 μL) | 200 μL |
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| MCC-DBN1-20-ORGO | 20 (40 μL) | 200 μL |
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| MCC-DBN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MCC-DBN1-20-GORE | 20 (40 μL) | 200 μL |
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| MCC-DBN1-20-GOOR | 20 (40 μL) | 200 μL |
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| MCC-DBN1-20-GOGO | 20 (40 μL) | 200 μL |
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| MCC-DBN1-20-GOGR | 20 (40 μL) | 200 μL |
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| MCC-DBN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MCC-DBN1-20-GRRE | 20 (40 μL) | 200 μL |
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| MCC-DBN1-20-GROR | 20 (40 μL) | 200 μL |
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| MCC-DBN1-20-GRGO | 20 (40 μL) | 200 μL |
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| MCC-DBN1-20-GRGR | 20 (40 μL) | 200 μL |
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| MCC-DBN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MCC-DBN1-20-AQRE | 20 (40 μL) | 200 μL |
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| MCC-DBN1-20-AQOR | 20 (40 μL) | 200 μL |
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| MCC-DBN1-20-AQGO | 20 (40 μL) | 200 μL |
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| MCC-DBN1-20-AQGR | 20 (40 μL) | 200 μL |
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| MCC-DBN1-20-AQAQ | 20 (40 μL) | 200 μL |
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DBN1 Gene Summary
The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Drebrin 1
Chromosome: CHR5: 176883613 -176900694
Locus: 5q35.3
MCC Gene Summary
This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Mutated In Colorectal Cancers
Chromosome: CHR5: 112357795 -112824527
Locus: 5q22.2
Gene Diseases
The MCC DBN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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