MBTPS1-TAF1C Fusion FISH Probe
The MBTPS1-TAF1C Fusion FISH Probe is used to confirm a fusion of the MBTPS1 and TAF1C genes. The fusion of the MBTPS1 and TAF1C genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MBTPS1-TAF1C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MBTPS1-TAF1C-20-RERE | 20 (40 μL) | 200 μL |
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| MBTPS1-TAF1C-20-REOR | 20 (40 μL) | 200 μL |
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| MBTPS1-TAF1C-20-REGO | 20 (40 μL) | 200 μL |
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| MBTPS1-TAF1C-20-REGR | 20 (40 μL) | 200 μL |
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| MBTPS1-TAF1C-20-REAQ | 20 (40 μL) | 200 μL |
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| MBTPS1-TAF1C-20-ORRE | 20 (40 μL) | 200 μL |
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| MBTPS1-TAF1C-20-OROR | 20 (40 μL) | 200 μL |
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| MBTPS1-TAF1C-20-ORGO | 20 (40 μL) | 200 μL |
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| MBTPS1-TAF1C-20-ORAQ | 20 (40 μL) | 200 μL |
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| MBTPS1-TAF1C-20-GORE | 20 (40 μL) | 200 μL |
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| MBTPS1-TAF1C-20-GOOR | 20 (40 μL) | 200 μL |
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| MBTPS1-TAF1C-20-GOGO | 20 (40 μL) | 200 μL |
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| MBTPS1-TAF1C-20-GOGR | 20 (40 μL) | 200 μL |
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| MBTPS1-TAF1C-20-GOAQ | 20 (40 μL) | 200 μL |
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| MBTPS1-TAF1C-20-GRRE | 20 (40 μL) | 200 μL |
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| MBTPS1-TAF1C-20-GROR | 20 (40 μL) | 200 μL |
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| MBTPS1-TAF1C-20-GRGO | 20 (40 μL) | 200 μL |
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| MBTPS1-TAF1C-20-GRGR | 20 (40 μL) | 200 μL |
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| MBTPS1-TAF1C-20-GRAQ | 20 (40 μL) | 200 μL |
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| MBTPS1-TAF1C-20-AQRE | 20 (40 μL) | 200 μL |
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| MBTPS1-TAF1C-20-AQOR | 20 (40 μL) | 200 μL |
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| MBTPS1-TAF1C-20-AQGO | 20 (40 μL) | 200 μL |
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| MBTPS1-TAF1C-20-AQGR | 20 (40 μL) | 200 μL |
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| MBTPS1-TAF1C-20-AQAQ | 20 (40 μL) | 200 μL |
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MBTPS1 Gene Summary
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction. [provided by RefSeq, Feb 2014]
Gene Name: Membrane Bound Transcription Factor Peptidase, Site 1
Chromosome: CHR16: 84087368 -84150517
Locus: 16q23.3-q24.1
TAF1C Gene Summary
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]
Gene Name: TATA-box Binding Protein Associated Factor, RNA Polymerase I Subunit C
Chromosome: CHR16: 84211452 -84220676
Locus: 16q24.1
Gene Diseases
The MBTPS1 TAF1C Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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