MBTPS1-CDH5 Fusion FISH Probe
The MBTPS1-CDH5 Fusion FISH Probe is used to confirm a fusion of the MBTPS1 and CDH5 genes. The fusion of the MBTPS1 and CDH5 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MBTPS1-CDH5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MBTPS1-CDH5-20-RERE | 20 (40 μL) | 200 μL |
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| MBTPS1-CDH5-20-REOR | 20 (40 μL) | 200 μL |
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| MBTPS1-CDH5-20-REGO | 20 (40 μL) | 200 μL |
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| MBTPS1-CDH5-20-REGR | 20 (40 μL) | 200 μL |
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| MBTPS1-CDH5-20-REAQ | 20 (40 μL) | 200 μL |
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| MBTPS1-CDH5-20-ORRE | 20 (40 μL) | 200 μL |
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| MBTPS1-CDH5-20-OROR | 20 (40 μL) | 200 μL |
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| MBTPS1-CDH5-20-ORGO | 20 (40 μL) | 200 μL |
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| MBTPS1-CDH5-20-ORAQ | 20 (40 μL) | 200 μL |
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| MBTPS1-CDH5-20-GORE | 20 (40 μL) | 200 μL |
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| MBTPS1-CDH5-20-GOOR | 20 (40 μL) | 200 μL |
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| MBTPS1-CDH5-20-GOGO | 20 (40 μL) | 200 μL |
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| MBTPS1-CDH5-20-GOGR | 20 (40 μL) | 200 μL |
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| MBTPS1-CDH5-20-GOAQ | 20 (40 μL) | 200 μL |
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| MBTPS1-CDH5-20-GRRE | 20 (40 μL) | 200 μL |
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| MBTPS1-CDH5-20-GROR | 20 (40 μL) | 200 μL |
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| MBTPS1-CDH5-20-GRGO | 20 (40 μL) | 200 μL |
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| MBTPS1-CDH5-20-GRGR | 20 (40 μL) | 200 μL |
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| MBTPS1-CDH5-20-GRAQ | 20 (40 μL) | 200 μL |
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| MBTPS1-CDH5-20-AQRE | 20 (40 μL) | 200 μL |
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| MBTPS1-CDH5-20-AQOR | 20 (40 μL) | 200 μL |
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| MBTPS1-CDH5-20-AQGO | 20 (40 μL) | 200 μL |
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| MBTPS1-CDH5-20-AQGR | 20 (40 μL) | 200 μL |
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| MBTPS1-CDH5-20-AQAQ | 20 (40 μL) | 200 μL |
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CDH5 Gene Summary
This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015]
Gene Name: Cadherin 5
Chromosome: CHR16: 66400524 -66438689
Locus: 16q21
MBTPS1 Gene Summary
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction. [provided by RefSeq, Feb 2014]
Gene Name: Membrane Bound Transcription Factor Peptidase, Site 1
Chromosome: CHR16: 84087368 -84150517
Locus: 16q23.3-q24.1
Gene Diseases
The MBTPS1 CDH5 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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