MBNL2-MADD Fusion FISH Probe
The MBNL2-MADD Fusion FISH Probe is used to confirm a fusion of the MBNL2 and MADD genes. The fusion of the MBNL2 and MADD genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MBNL2-MADD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MBNL2-MADD-20-RERE | 20 (40 μL) | 200 μL |
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| MBNL2-MADD-20-REOR | 20 (40 μL) | 200 μL |
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| MBNL2-MADD-20-REGO | 20 (40 μL) | 200 μL |
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| MBNL2-MADD-20-REGR | 20 (40 μL) | 200 μL |
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| MBNL2-MADD-20-REAQ | 20 (40 μL) | 200 μL |
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| MBNL2-MADD-20-ORRE | 20 (40 μL) | 200 μL |
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| MBNL2-MADD-20-OROR | 20 (40 μL) | 200 μL |
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| MBNL2-MADD-20-ORGO | 20 (40 μL) | 200 μL |
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| MBNL2-MADD-20-ORAQ | 20 (40 μL) | 200 μL |
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| MBNL2-MADD-20-GORE | 20 (40 μL) | 200 μL |
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| MBNL2-MADD-20-GOOR | 20 (40 μL) | 200 μL |
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| MBNL2-MADD-20-GOGO | 20 (40 μL) | 200 μL |
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| MBNL2-MADD-20-GOGR | 20 (40 μL) | 200 μL |
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| MBNL2-MADD-20-GOAQ | 20 (40 μL) | 200 μL |
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| MBNL2-MADD-20-GRRE | 20 (40 μL) | 200 μL |
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| MBNL2-MADD-20-GROR | 20 (40 μL) | 200 μL |
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| MBNL2-MADD-20-GRGO | 20 (40 μL) | 200 μL |
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| MBNL2-MADD-20-GRGR | 20 (40 μL) | 200 μL |
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| MBNL2-MADD-20-GRAQ | 20 (40 μL) | 200 μL |
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| MBNL2-MADD-20-AQRE | 20 (40 μL) | 200 μL |
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| MBNL2-MADD-20-AQOR | 20 (40 μL) | 200 μL |
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| MBNL2-MADD-20-AQGO | 20 (40 μL) | 200 μL |
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| MBNL2-MADD-20-AQGR | 20 (40 μL) | 200 μL |
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| MBNL2-MADD-20-AQAQ | 20 (40 μL) | 200 μL |
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MADD Gene Summary
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: MAP Kinase Activating Death Domain
Chromosome: CHR11: 47290926 -47351582
Locus: 11p11.2
MBNL2 Gene Summary
This gene is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. This gene encodes a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. [provided by RefSeq, Mar 2012]
Gene Name: Muscleblind Like Splicing Regulator 2
Chromosome: CHR13: 97874573 -98046374
Locus: 13q32.1
Gene Diseases
The MBNL2 MADD Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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