MBNL2-GLI3 Fusion FISH Probe
The MBNL2-GLI3 Fusion FISH Probe is used to confirm a fusion of the MBNL2 and GLI3 genes. The fusion of the MBNL2 and GLI3 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MBNL2-GLI3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MBNL2-GLI3-20-RERE | 20 (40 μL) | 200 μL |
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| MBNL2-GLI3-20-REOR | 20 (40 μL) | 200 μL |
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| MBNL2-GLI3-20-REGO | 20 (40 μL) | 200 μL |
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| MBNL2-GLI3-20-REGR | 20 (40 μL) | 200 μL |
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| MBNL2-GLI3-20-REAQ | 20 (40 μL) | 200 μL |
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| MBNL2-GLI3-20-ORRE | 20 (40 μL) | 200 μL |
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| MBNL2-GLI3-20-OROR | 20 (40 μL) | 200 μL |
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| MBNL2-GLI3-20-ORGO | 20 (40 μL) | 200 μL |
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| MBNL2-GLI3-20-ORAQ | 20 (40 μL) | 200 μL |
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| MBNL2-GLI3-20-GORE | 20 (40 μL) | 200 μL |
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| MBNL2-GLI3-20-GOOR | 20 (40 μL) | 200 μL |
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| MBNL2-GLI3-20-GOGO | 20 (40 μL) | 200 μL |
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| MBNL2-GLI3-20-GOGR | 20 (40 μL) | 200 μL |
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| MBNL2-GLI3-20-GOAQ | 20 (40 μL) | 200 μL |
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| MBNL2-GLI3-20-GRRE | 20 (40 μL) | 200 μL |
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| MBNL2-GLI3-20-GROR | 20 (40 μL) | 200 μL |
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| MBNL2-GLI3-20-GRGO | 20 (40 μL) | 200 μL |
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| MBNL2-GLI3-20-GRGR | 20 (40 μL) | 200 μL |
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| MBNL2-GLI3-20-GRAQ | 20 (40 μL) | 200 μL |
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| MBNL2-GLI3-20-AQRE | 20 (40 μL) | 200 μL |
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| MBNL2-GLI3-20-AQOR | 20 (40 μL) | 200 μL |
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| MBNL2-GLI3-20-AQGO | 20 (40 μL) | 200 μL |
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| MBNL2-GLI3-20-AQGR | 20 (40 μL) | 200 μL |
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| MBNL2-GLI3-20-AQAQ | 20 (40 μL) | 200 μL |
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GLI3 Gene Summary
This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]
Gene Name: GLI Family Zinc Finger 3
Chromosome: CHR7: 42000547 -42276618
Locus: 7p14.1
MBNL2 Gene Summary
This gene is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. This gene encodes a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. [provided by RefSeq, Mar 2012]
Gene Name: Muscleblind Like Splicing Regulator 2
Chromosome: CHR13: 97874573 -98046374
Locus: 13q32.1
Gene Diseases
The MBNL2 GLI3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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