MBNL1-SGSM3 Fusion FISH Probe
The MBNL1-SGSM3 Fusion FISH Probe is used to confirm a fusion of the MBNL1 and SGSM3 genes. The fusion of the MBNL1 and SGSM3 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MBNL1-SGSM3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MBNL1-SGSM3-20-RERE | 20 (40 μL) | 200 μL |
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| MBNL1-SGSM3-20-REOR | 20 (40 μL) | 200 μL |
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| MBNL1-SGSM3-20-REGO | 20 (40 μL) | 200 μL |
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| MBNL1-SGSM3-20-REGR | 20 (40 μL) | 200 μL |
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| MBNL1-SGSM3-20-REAQ | 20 (40 μL) | 200 μL |
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| MBNL1-SGSM3-20-ORRE | 20 (40 μL) | 200 μL |
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| MBNL1-SGSM3-20-OROR | 20 (40 μL) | 200 μL |
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| MBNL1-SGSM3-20-ORGO | 20 (40 μL) | 200 μL |
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| MBNL1-SGSM3-20-ORAQ | 20 (40 μL) | 200 μL |
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| MBNL1-SGSM3-20-GORE | 20 (40 μL) | 200 μL |
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| MBNL1-SGSM3-20-GOOR | 20 (40 μL) | 200 μL |
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| MBNL1-SGSM3-20-GOGO | 20 (40 μL) | 200 μL |
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| MBNL1-SGSM3-20-GOGR | 20 (40 μL) | 200 μL |
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| MBNL1-SGSM3-20-GOAQ | 20 (40 μL) | 200 μL |
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| MBNL1-SGSM3-20-GRRE | 20 (40 μL) | 200 μL |
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| MBNL1-SGSM3-20-GROR | 20 (40 μL) | 200 μL |
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| MBNL1-SGSM3-20-GRGO | 20 (40 μL) | 200 μL |
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| MBNL1-SGSM3-20-GRGR | 20 (40 μL) | 200 μL |
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| MBNL1-SGSM3-20-GRAQ | 20 (40 μL) | 200 μL |
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| MBNL1-SGSM3-20-AQRE | 20 (40 μL) | 200 μL |
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| MBNL1-SGSM3-20-AQOR | 20 (40 μL) | 200 μL |
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| MBNL1-SGSM3-20-AQGO | 20 (40 μL) | 200 μL |
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| MBNL1-SGSM3-20-AQGR | 20 (40 μL) | 200 μL |
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| MBNL1-SGSM3-20-AQAQ | 20 (40 μL) | 200 μL |
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MBNL1 Gene Summary
This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities. [provided by RefSeq, Sep 2015]
Gene Name: Muscleblind Like Splicing Regulator 1
Chromosome: CHR3: 151985828 -152183568
Locus: 3q25.1-q25.2
SGSM3 Gene Summary
The Small G Protein Signaling Modulator 3 (SGSM3) gene is located on chr22 :40766594-40806293 at 22q13.1.
Gene Name: Small G Protein Signaling Modulator 3
Chromosome: CHR22: 40766594 -40806293
Locus: 22q13.1
Gene Diseases
The MBNL1 SGSM3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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