MBD3-GAK Fusion FISH Probe
The MBD3-GAK Fusion FISH Probe is used to confirm a fusion of the MBD3 and GAK genes. The fusion of the MBD3 and GAK genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MBD3-GAK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MBD3-GAK-20-RERE | 20 (40 μL) | 200 μL |
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| MBD3-GAK-20-REOR | 20 (40 μL) | 200 μL |
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| MBD3-GAK-20-REGO | 20 (40 μL) | 200 μL |
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| MBD3-GAK-20-REGR | 20 (40 μL) | 200 μL |
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| MBD3-GAK-20-REAQ | 20 (40 μL) | 200 μL |
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| MBD3-GAK-20-ORRE | 20 (40 μL) | 200 μL |
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| MBD3-GAK-20-OROR | 20 (40 μL) | 200 μL |
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| MBD3-GAK-20-ORGO | 20 (40 μL) | 200 μL |
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| MBD3-GAK-20-ORAQ | 20 (40 μL) | 200 μL |
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| MBD3-GAK-20-GORE | 20 (40 μL) | 200 μL |
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| MBD3-GAK-20-GOOR | 20 (40 μL) | 200 μL |
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| MBD3-GAK-20-GOGO | 20 (40 μL) | 200 μL |
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| MBD3-GAK-20-GOGR | 20 (40 μL) | 200 μL |
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| MBD3-GAK-20-GOAQ | 20 (40 μL) | 200 μL |
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| MBD3-GAK-20-GRRE | 20 (40 μL) | 200 μL |
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| MBD3-GAK-20-GROR | 20 (40 μL) | 200 μL |
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| MBD3-GAK-20-GRGO | 20 (40 μL) | 200 μL |
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| MBD3-GAK-20-GRGR | 20 (40 μL) | 200 μL |
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| MBD3-GAK-20-GRAQ | 20 (40 μL) | 200 μL |
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| MBD3-GAK-20-AQRE | 20 (40 μL) | 200 μL |
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| MBD3-GAK-20-AQOR | 20 (40 μL) | 200 μL |
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| MBD3-GAK-20-AQGO | 20 (40 μL) | 200 μL |
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| MBD3-GAK-20-AQGR | 20 (40 μL) | 200 μL |
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| MBD3-GAK-20-AQAQ | 20 (40 μL) | 200 μL |
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GAK Gene Summary
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Gene Name: Cyclin G Associated Kinase
Chromosome: CHR4: 843064 -926174
Locus: 4p16.3
MBD3 Gene Summary
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Gene Name: Methyl-CpG Binding Domain Protein 3
Chromosome: CHR19: 1576677 -1592652
Locus: 19p13.3
Gene Diseases
The MBD3 GAK Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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