MAX-ACTN1 Fusion FISH Probe
The MAX-ACTN1 Fusion FISH Probe is used to confirm a fusion of the MAX and ACTN1 genes. The fusion of the MAX and ACTN1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAX-ACTN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAX-ACTN1-20-RERE | 20 (40 μL) | 200 μL |
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| MAX-ACTN1-20-REOR | 20 (40 μL) | 200 μL |
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| MAX-ACTN1-20-REGO | 20 (40 μL) | 200 μL |
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| MAX-ACTN1-20-REGR | 20 (40 μL) | 200 μL |
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| MAX-ACTN1-20-REAQ | 20 (40 μL) | 200 μL |
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| MAX-ACTN1-20-ORRE | 20 (40 μL) | 200 μL |
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| MAX-ACTN1-20-OROR | 20 (40 μL) | 200 μL |
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| MAX-ACTN1-20-ORGO | 20 (40 μL) | 200 μL |
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| MAX-ACTN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAX-ACTN1-20-GORE | 20 (40 μL) | 200 μL |
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| MAX-ACTN1-20-GOOR | 20 (40 μL) | 200 μL |
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| MAX-ACTN1-20-GOGO | 20 (40 μL) | 200 μL |
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| MAX-ACTN1-20-GOGR | 20 (40 μL) | 200 μL |
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| MAX-ACTN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAX-ACTN1-20-GRRE | 20 (40 μL) | 200 μL |
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| MAX-ACTN1-20-GROR | 20 (40 μL) | 200 μL |
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| MAX-ACTN1-20-GRGO | 20 (40 μL) | 200 μL |
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| MAX-ACTN1-20-GRGR | 20 (40 μL) | 200 μL |
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| MAX-ACTN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAX-ACTN1-20-AQRE | 20 (40 μL) | 200 μL |
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| MAX-ACTN1-20-AQOR | 20 (40 μL) | 200 μL |
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| MAX-ACTN1-20-AQGO | 20 (40 μL) | 200 μL |
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| MAX-ACTN1-20-AQGR | 20 (40 μL) | 200 μL |
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| MAX-ACTN1-20-AQAQ | 20 (40 μL) | 200 μL |
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ACTN1 Gene Summary
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Actinin Alpha 1
Chromosome: CHR14: 69340839 -69446083
Locus: 14q22-q24
MAX Gene Summary
The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Name: MYC Associated Factor X
Chromosome: CHR14: 65472891 -65569227
Locus: 14q23.3
Gene Diseases
The MAX ACTN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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