MATR3-PCDHA2 Fusion FISH Probe
The MATR3-PCDHA2 Fusion FISH Probe is used to confirm a fusion of the MATR3 and PCDHA2 genes. The fusion of the MATR3 and PCDHA2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MATR3-PCDHA2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MATR3-PCDHA2-20-RERE | 20 (40 μL) | 200 μL |
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| MATR3-PCDHA2-20-REOR | 20 (40 μL) | 200 μL |
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| MATR3-PCDHA2-20-REGO | 20 (40 μL) | 200 μL |
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| MATR3-PCDHA2-20-REGR | 20 (40 μL) | 200 μL |
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| MATR3-PCDHA2-20-REAQ | 20 (40 μL) | 200 μL |
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| MATR3-PCDHA2-20-ORRE | 20 (40 μL) | 200 μL |
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| MATR3-PCDHA2-20-OROR | 20 (40 μL) | 200 μL |
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| MATR3-PCDHA2-20-ORGO | 20 (40 μL) | 200 μL |
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| MATR3-PCDHA2-20-ORAQ | 20 (40 μL) | 200 μL |
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| MATR3-PCDHA2-20-GORE | 20 (40 μL) | 200 μL |
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| MATR3-PCDHA2-20-GOOR | 20 (40 μL) | 200 μL |
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| MATR3-PCDHA2-20-GOGO | 20 (40 μL) | 200 μL |
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| MATR3-PCDHA2-20-GOGR | 20 (40 μL) | 200 μL |
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| MATR3-PCDHA2-20-GOAQ | 20 (40 μL) | 200 μL |
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| MATR3-PCDHA2-20-GRRE | 20 (40 μL) | 200 μL |
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| MATR3-PCDHA2-20-GROR | 20 (40 μL) | 200 μL |
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| MATR3-PCDHA2-20-GRGO | 20 (40 μL) | 200 μL |
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| MATR3-PCDHA2-20-GRGR | 20 (40 μL) | 200 μL |
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| MATR3-PCDHA2-20-GRAQ | 20 (40 μL) | 200 μL |
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| MATR3-PCDHA2-20-AQRE | 20 (40 μL) | 200 μL |
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| MATR3-PCDHA2-20-AQOR | 20 (40 μL) | 200 μL |
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| MATR3-PCDHA2-20-AQGO | 20 (40 μL) | 200 μL |
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| MATR3-PCDHA2-20-AQGR | 20 (40 μL) | 200 μL |
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| MATR3-PCDHA2-20-AQAQ | 20 (40 μL) | 200 μL |
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MATR3 Gene Summary
This gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. Mutations of this gene are associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts composed of the upstream small nucleolar RNA host gene 4 (non-protein coding) and matrin 3 gene sequence, have been identified. Pseudogenes of this gene are located on chromosomes 1 and X. [provided by RefSeq, Aug 2013]
Gene Name: Matrin 3
Chromosome: CHR5: 138609440 -138667366
Locus: 5q31.2
PCDHA2 Gene Summary
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
Gene Name: Protocadherin Alpha 2
Chromosome: CHR5: 140174443 -140391929
Locus: 5q31.3
Gene Diseases
The MATR3 PCDHA2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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