MARK3-FBLN5 Fusion FISH Probe
The MARK3-FBLN5 Fusion FISH Probe is used to confirm a fusion of the MARK3 and FBLN5 genes. The fusion of the MARK3 and FBLN5 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MARK3-FBLN5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MARK3-FBLN5-20-RERE | 20 (40 μL) | 200 μL |
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| MARK3-FBLN5-20-REOR | 20 (40 μL) | 200 μL |
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| MARK3-FBLN5-20-REGO | 20 (40 μL) | 200 μL |
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| MARK3-FBLN5-20-REGR | 20 (40 μL) | 200 μL |
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| MARK3-FBLN5-20-REAQ | 20 (40 μL) | 200 μL |
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| MARK3-FBLN5-20-ORRE | 20 (40 μL) | 200 μL |
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| MARK3-FBLN5-20-OROR | 20 (40 μL) | 200 μL |
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| MARK3-FBLN5-20-ORGO | 20 (40 μL) | 200 μL |
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| MARK3-FBLN5-20-ORAQ | 20 (40 μL) | 200 μL |
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| MARK3-FBLN5-20-GORE | 20 (40 μL) | 200 μL |
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| MARK3-FBLN5-20-GOOR | 20 (40 μL) | 200 μL |
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| MARK3-FBLN5-20-GOGO | 20 (40 μL) | 200 μL |
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| MARK3-FBLN5-20-GOGR | 20 (40 μL) | 200 μL |
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| MARK3-FBLN5-20-GOAQ | 20 (40 μL) | 200 μL |
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| MARK3-FBLN5-20-GRRE | 20 (40 μL) | 200 μL |
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| MARK3-FBLN5-20-GROR | 20 (40 μL) | 200 μL |
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| MARK3-FBLN5-20-GRGO | 20 (40 μL) | 200 μL |
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| MARK3-FBLN5-20-GRGR | 20 (40 μL) | 200 μL |
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| MARK3-FBLN5-20-GRAQ | 20 (40 μL) | 200 μL |
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| MARK3-FBLN5-20-AQRE | 20 (40 μL) | 200 μL |
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| MARK3-FBLN5-20-AQOR | 20 (40 μL) | 200 μL |
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| MARK3-FBLN5-20-AQGO | 20 (40 μL) | 200 μL |
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| MARK3-FBLN5-20-AQGR | 20 (40 μL) | 200 μL |
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| MARK3-FBLN5-20-AQAQ | 20 (40 μL) | 200 μL |
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MARK3 Gene Summary
The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Microtubule Affinity Regulating Kinase 3
Chromosome: CHR14: 103851700 -103970166
Locus: 14q32.32-q32.33
FBLN5 Gene Summary
The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]
Gene Name: Fibulin 5
Chromosome: CHR14: 92335754 -92414046
Locus: 14q32.12
Gene Diseases
The MARK3 FBLN5 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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