MARK2-DLAT Fusion FISH Probe
The MARK2-DLAT Fusion FISH Probe is used to confirm a fusion of the MARK2 and DLAT genes. The fusion of the MARK2 and DLAT genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MARK2-DLAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MARK2-DLAT-20-RERE | 20 (40 μL) | 200 μL |
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| MARK2-DLAT-20-REOR | 20 (40 μL) | 200 μL |
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| MARK2-DLAT-20-REGO | 20 (40 μL) | 200 μL |
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| MARK2-DLAT-20-REGR | 20 (40 μL) | 200 μL |
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| MARK2-DLAT-20-REAQ | 20 (40 μL) | 200 μL |
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| MARK2-DLAT-20-ORRE | 20 (40 μL) | 200 μL |
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| MARK2-DLAT-20-OROR | 20 (40 μL) | 200 μL |
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| MARK2-DLAT-20-ORGO | 20 (40 μL) | 200 μL |
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| MARK2-DLAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| MARK2-DLAT-20-GORE | 20 (40 μL) | 200 μL |
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| MARK2-DLAT-20-GOOR | 20 (40 μL) | 200 μL |
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| MARK2-DLAT-20-GOGO | 20 (40 μL) | 200 μL |
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| MARK2-DLAT-20-GOGR | 20 (40 μL) | 200 μL |
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| MARK2-DLAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| MARK2-DLAT-20-GRRE | 20 (40 μL) | 200 μL |
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| MARK2-DLAT-20-GROR | 20 (40 μL) | 200 μL |
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| MARK2-DLAT-20-GRGO | 20 (40 μL) | 200 μL |
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| MARK2-DLAT-20-GRGR | 20 (40 μL) | 200 μL |
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| MARK2-DLAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| MARK2-DLAT-20-AQRE | 20 (40 μL) | 200 μL |
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| MARK2-DLAT-20-AQOR | 20 (40 μL) | 200 μL |
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| MARK2-DLAT-20-AQGO | 20 (40 μL) | 200 μL |
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| MARK2-DLAT-20-AQGR | 20 (40 μL) | 200 μL |
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| MARK2-DLAT-20-AQAQ | 20 (40 μL) | 200 μL |
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DLAT Gene Summary
This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.[provided by RefSeq, Oct 2009]
Gene Name: Dihydrolipoamide S-acetyltransferase
Chromosome: CHR11: 111895537 -111935002
Locus: 11q23.1
MARK2 Gene Summary
This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
Gene Name: Microtubule Affinity Regulating Kinase 2
Chromosome: CHR11: 63606399 -63678492
Locus: 11q13.1
Gene Diseases
The MARK2 DLAT Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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