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MARK2-BUB1B Fusion FISH Probe

The MARK2-BUB1B Fusion FISH Probe is used to confirm a fusion of the MARK2 and BUB1B genes. The fusion of the MARK2 and BUB1B genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
MARK2-BUB1B-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
MARK2-BUB1B-20-RERE 20 (40 μL) 200 μL
MARK2-BUB1B-20-REOR 20 (40 μL) 200 μL
MARK2-BUB1B-20-REGO 20 (40 μL) 200 μL
MARK2-BUB1B-20-REGR 20 (40 μL) 200 μL
MARK2-BUB1B-20-REAQ 20 (40 μL) 200 μL
MARK2-BUB1B-20-ORRE 20 (40 μL) 200 μL
MARK2-BUB1B-20-OROR 20 (40 μL) 200 μL
MARK2-BUB1B-20-ORGO 20 (40 μL) 200 μL
MARK2-BUB1B-20-ORAQ 20 (40 μL) 200 μL
MARK2-BUB1B-20-GORE 20 (40 μL) 200 μL
MARK2-BUB1B-20-GOOR 20 (40 μL) 200 μL
MARK2-BUB1B-20-GOGO 20 (40 μL) 200 μL
MARK2-BUB1B-20-GOGR 20 (40 μL) 200 μL
MARK2-BUB1B-20-GOAQ 20 (40 μL) 200 μL
MARK2-BUB1B-20-GRRE 20 (40 μL) 200 μL
MARK2-BUB1B-20-GROR 20 (40 μL) 200 μL
MARK2-BUB1B-20-GRGO 20 (40 μL) 200 μL
MARK2-BUB1B-20-GRGR 20 (40 μL) 200 μL
MARK2-BUB1B-20-GRAQ 20 (40 μL) 200 μL
MARK2-BUB1B-20-AQRE 20 (40 μL) 200 μL
MARK2-BUB1B-20-AQOR 20 (40 μL) 200 μL
MARK2-BUB1B-20-AQGO 20 (40 μL) 200 μL
MARK2-BUB1B-20-AQGR 20 (40 μL) 200 μL
MARK2-BUB1B-20-AQAQ 20 (40 μL) 200 μL

BUB1B Gene Summary

This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]

Gene Name: BUB1 Mitotic Checkpoint Serine/threonine Kinase B

Chromosome: CHR15: 40453209 -40513337

Locus: 15q15.1

MARK2 Gene Summary

This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

Gene Name: Microtubule Affinity Regulating Kinase 2

Chromosome: CHR11: 63606399 -63678492

Locus: 11q13.1

Gene Diseases

The MARK2 BUB1B Fusion has been associated with the following diseases:

Disease Name
Lung Squamous Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.