MAPKBP1-VPS39 Fusion FISH Probe
The MAPKBP1-VPS39 Fusion FISH Probe is used to confirm a fusion of the MAPKBP1 and VPS39 genes. The fusion of the MAPKBP1 and VPS39 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAPKBP1-VPS39-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAPKBP1-VPS39-20-RERE | 20 (40 μL) | 200 μL |
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| MAPKBP1-VPS39-20-REOR | 20 (40 μL) | 200 μL |
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| MAPKBP1-VPS39-20-REGO | 20 (40 μL) | 200 μL |
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| MAPKBP1-VPS39-20-REGR | 20 (40 μL) | 200 μL |
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| MAPKBP1-VPS39-20-REAQ | 20 (40 μL) | 200 μL |
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| MAPKBP1-VPS39-20-ORRE | 20 (40 μL) | 200 μL |
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| MAPKBP1-VPS39-20-OROR | 20 (40 μL) | 200 μL |
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| MAPKBP1-VPS39-20-ORGO | 20 (40 μL) | 200 μL |
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| MAPKBP1-VPS39-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAPKBP1-VPS39-20-GORE | 20 (40 μL) | 200 μL |
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| MAPKBP1-VPS39-20-GOOR | 20 (40 μL) | 200 μL |
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| MAPKBP1-VPS39-20-GOGO | 20 (40 μL) | 200 μL |
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| MAPKBP1-VPS39-20-GOGR | 20 (40 μL) | 200 μL |
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| MAPKBP1-VPS39-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAPKBP1-VPS39-20-GRRE | 20 (40 μL) | 200 μL |
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| MAPKBP1-VPS39-20-GROR | 20 (40 μL) | 200 μL |
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| MAPKBP1-VPS39-20-GRGO | 20 (40 μL) | 200 μL |
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| MAPKBP1-VPS39-20-GRGR | 20 (40 μL) | 200 μL |
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| MAPKBP1-VPS39-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAPKBP1-VPS39-20-AQRE | 20 (40 μL) | 200 μL |
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| MAPKBP1-VPS39-20-AQOR | 20 (40 μL) | 200 μL |
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| MAPKBP1-VPS39-20-AQGO | 20 (40 μL) | 200 μL |
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| MAPKBP1-VPS39-20-AQGR | 20 (40 μL) | 200 μL |
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| MAPKBP1-VPS39-20-AQAQ | 20 (40 μL) | 200 μL |
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MAPKBP1 Gene Summary
This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients. [provided by RefSeq, May 2017]
Gene Name: Mitogen-activated Protein Kinase Binding Protein 1
Chromosome: CHR15: 42066631 -42120053
Locus: 15q15.1
VPS39 Gene Summary
This gene encodes a protein that may promote clustering and fusion of late endosomes and lysosomes. The protein may also act as an adaptor protein that modulates the transforming growth factor-beta response by coupling the transforming growth factor-beta receptor complex to the Smad pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Name: VPS39, HOPS Complex Subunit
Chromosome: CHR15: 42450898 -42500502
Locus: 15q15.1
Gene Diseases
The MAPKBP1 VPS39 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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