MAPKAPK5-ALDH2 Fusion FISH Probe
The MAPKAPK5-ALDH2 Fusion FISH Probe is used to confirm a fusion of the MAPKAPK5 and ALDH2 genes. The fusion of the MAPKAPK5 and ALDH2 genes has been associated with Lung Adenocarcinoma, and Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAPKAPK5-ALDH2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAPKAPK5-ALDH2-20-RERE | 20 (40 μL) | 200 μL |
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| MAPKAPK5-ALDH2-20-REOR | 20 (40 μL) | 200 μL |
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| MAPKAPK5-ALDH2-20-REGO | 20 (40 μL) | 200 μL |
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| MAPKAPK5-ALDH2-20-REGR | 20 (40 μL) | 200 μL |
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| MAPKAPK5-ALDH2-20-REAQ | 20 (40 μL) | 200 μL |
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| MAPKAPK5-ALDH2-20-ORRE | 20 (40 μL) | 200 μL |
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| MAPKAPK5-ALDH2-20-OROR | 20 (40 μL) | 200 μL |
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| MAPKAPK5-ALDH2-20-ORGO | 20 (40 μL) | 200 μL |
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| MAPKAPK5-ALDH2-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAPKAPK5-ALDH2-20-GORE | 20 (40 μL) | 200 μL |
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| MAPKAPK5-ALDH2-20-GOOR | 20 (40 μL) | 200 μL |
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| MAPKAPK5-ALDH2-20-GOGO | 20 (40 μL) | 200 μL |
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| MAPKAPK5-ALDH2-20-GOGR | 20 (40 μL) | 200 μL |
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| MAPKAPK5-ALDH2-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAPKAPK5-ALDH2-20-GRRE | 20 (40 μL) | 200 μL |
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| MAPKAPK5-ALDH2-20-GROR | 20 (40 μL) | 200 μL |
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| MAPKAPK5-ALDH2-20-GRGO | 20 (40 μL) | 200 μL |
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| MAPKAPK5-ALDH2-20-GRGR | 20 (40 μL) | 200 μL |
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| MAPKAPK5-ALDH2-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAPKAPK5-ALDH2-20-AQRE | 20 (40 μL) | 200 μL |
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| MAPKAPK5-ALDH2-20-AQOR | 20 (40 μL) | 200 μL |
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| MAPKAPK5-ALDH2-20-AQGO | 20 (40 μL) | 200 μL |
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| MAPKAPK5-ALDH2-20-AQGR | 20 (40 μL) | 200 μL |
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| MAPKAPK5-ALDH2-20-AQAQ | 20 (40 μL) | 200 μL |
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ALDH2 Gene Summary
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2016]
Gene Name: Aldehyde Dehydrogenase 2 Family (mitochondrial)
Chromosome: CHR12: 112204690 -112247789
Locus: 12q24.12
MAPKAPK5 Gene Summary
The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]
Gene Name: Mitogen-activated Protein Kinase-activated Protein Kinase 5
Chromosome: CHR12: 112280278 -112331228
Locus: 12q24.12-q24.13
Gene Diseases
The MAPKAPK5 ALDH2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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