MAPKAPK3-HEMK1 Fusion FISH Probe
The MAPKAPK3-HEMK1 Fusion FISH Probe is used to confirm a fusion of the MAPKAPK3 and HEMK1 genes. The fusion of the MAPKAPK3 and HEMK1 genes has been associated with Lung Adenocarcinoma, and Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAPKAPK3-HEMK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAPKAPK3-HEMK1-20-RERE | 20 (40 μL) | 200 μL |
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| MAPKAPK3-HEMK1-20-REOR | 20 (40 μL) | 200 μL |
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| MAPKAPK3-HEMK1-20-REGO | 20 (40 μL) | 200 μL |
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| MAPKAPK3-HEMK1-20-REGR | 20 (40 μL) | 200 μL |
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| MAPKAPK3-HEMK1-20-REAQ | 20 (40 μL) | 200 μL |
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| MAPKAPK3-HEMK1-20-ORRE | 20 (40 μL) | 200 μL |
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| MAPKAPK3-HEMK1-20-OROR | 20 (40 μL) | 200 μL |
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| MAPKAPK3-HEMK1-20-ORGO | 20 (40 μL) | 200 μL |
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| MAPKAPK3-HEMK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAPKAPK3-HEMK1-20-GORE | 20 (40 μL) | 200 μL |
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| MAPKAPK3-HEMK1-20-GOOR | 20 (40 μL) | 200 μL |
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| MAPKAPK3-HEMK1-20-GOGO | 20 (40 μL) | 200 μL |
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| MAPKAPK3-HEMK1-20-GOGR | 20 (40 μL) | 200 μL |
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| MAPKAPK3-HEMK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAPKAPK3-HEMK1-20-GRRE | 20 (40 μL) | 200 μL |
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| MAPKAPK3-HEMK1-20-GROR | 20 (40 μL) | 200 μL |
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| MAPKAPK3-HEMK1-20-GRGO | 20 (40 μL) | 200 μL |
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| MAPKAPK3-HEMK1-20-GRGR | 20 (40 μL) | 200 μL |
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| MAPKAPK3-HEMK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAPKAPK3-HEMK1-20-AQRE | 20 (40 μL) | 200 μL |
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| MAPKAPK3-HEMK1-20-AQOR | 20 (40 μL) | 200 μL |
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| MAPKAPK3-HEMK1-20-AQGO | 20 (40 μL) | 200 μL |
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| MAPKAPK3-HEMK1-20-AQGR | 20 (40 μL) | 200 μL |
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| MAPKAPK3-HEMK1-20-AQAQ | 20 (40 μL) | 200 μL |
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MAPKAPK3 Gene Summary
This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]
Gene Name: Mitogen-activated Protein Kinase-activated Protein Kinase 3
Chromosome: CHR3: 50649292 -50686728
Locus: 3p21.2
HEMK1 Gene Summary
The HemK Methyltransferase Family Member 1 (HEMK1) gene is located on chr3 :50606908-50622421 at 3p21.31.
Gene Name: HemK Methyltransferase Family Member 1
Chromosome: CHR3: 50606908 -50622421
Locus: 3p21.31
Gene Diseases
The MAPKAPK3 HEMK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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