MAPKAPK2-SRGAP2 Fusion FISH Probe
The MAPKAPK2-SRGAP2 Fusion FISH Probe is used to confirm a fusion of the MAPKAPK2 and SRGAP2 genes. The fusion of the MAPKAPK2 and SRGAP2 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAPKAPK2-SRGAP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAPKAPK2-SRGAP2-20-RERE | 20 (40 μL) | 200 μL |
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| MAPKAPK2-SRGAP2-20-REOR | 20 (40 μL) | 200 μL |
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| MAPKAPK2-SRGAP2-20-REGO | 20 (40 μL) | 200 μL |
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| MAPKAPK2-SRGAP2-20-REGR | 20 (40 μL) | 200 μL |
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| MAPKAPK2-SRGAP2-20-REAQ | 20 (40 μL) | 200 μL |
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| MAPKAPK2-SRGAP2-20-ORRE | 20 (40 μL) | 200 μL |
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| MAPKAPK2-SRGAP2-20-OROR | 20 (40 μL) | 200 μL |
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| MAPKAPK2-SRGAP2-20-ORGO | 20 (40 μL) | 200 μL |
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| MAPKAPK2-SRGAP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAPKAPK2-SRGAP2-20-GORE | 20 (40 μL) | 200 μL |
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| MAPKAPK2-SRGAP2-20-GOOR | 20 (40 μL) | 200 μL |
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| MAPKAPK2-SRGAP2-20-GOGO | 20 (40 μL) | 200 μL |
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| MAPKAPK2-SRGAP2-20-GOGR | 20 (40 μL) | 200 μL |
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| MAPKAPK2-SRGAP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAPKAPK2-SRGAP2-20-GRRE | 20 (40 μL) | 200 μL |
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| MAPKAPK2-SRGAP2-20-GROR | 20 (40 μL) | 200 μL |
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| MAPKAPK2-SRGAP2-20-GRGO | 20 (40 μL) | 200 μL |
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| MAPKAPK2-SRGAP2-20-GRGR | 20 (40 μL) | 200 μL |
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| MAPKAPK2-SRGAP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAPKAPK2-SRGAP2-20-AQRE | 20 (40 μL) | 200 μL |
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| MAPKAPK2-SRGAP2-20-AQOR | 20 (40 μL) | 200 μL |
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| MAPKAPK2-SRGAP2-20-AQGO | 20 (40 μL) | 200 μL |
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| MAPKAPK2-SRGAP2-20-AQGR | 20 (40 μL) | 200 μL |
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| MAPKAPK2-SRGAP2-20-AQAQ | 20 (40 μL) | 200 μL |
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MAPKAPK2 Gene Summary
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase-activated Protein Kinase 2
Chromosome: CHR1: 206858364 -206907630
Locus: 1q32.1
SRGAP2 Gene Summary
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014]
Gene Name: SLIT-ROBO Rho GTPase Activating Protein 2
Chromosome: CHR1: 206516199 -206637783
Locus: 1q32.1
Gene Diseases
The MAPKAPK2 SRGAP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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