MAPKAPK2-PLA2G2A Fusion FISH Probe
The MAPKAPK2-PLA2G2A Fusion FISH Probe is used to confirm a fusion of the MAPKAPK2 and PLA2G2A genes. The fusion of the MAPKAPK2 and PLA2G2A genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAPKAPK2-PLA2G2A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAPKAPK2-PLA2G2A-20-RERE | 20 (40 μL) | 200 μL |
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| MAPKAPK2-PLA2G2A-20-REOR | 20 (40 μL) | 200 μL |
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| MAPKAPK2-PLA2G2A-20-REGO | 20 (40 μL) | 200 μL |
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| MAPKAPK2-PLA2G2A-20-REGR | 20 (40 μL) | 200 μL |
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| MAPKAPK2-PLA2G2A-20-REAQ | 20 (40 μL) | 200 μL |
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| MAPKAPK2-PLA2G2A-20-ORRE | 20 (40 μL) | 200 μL |
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| MAPKAPK2-PLA2G2A-20-OROR | 20 (40 μL) | 200 μL |
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| MAPKAPK2-PLA2G2A-20-ORGO | 20 (40 μL) | 200 μL |
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| MAPKAPK2-PLA2G2A-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAPKAPK2-PLA2G2A-20-GORE | 20 (40 μL) | 200 μL |
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| MAPKAPK2-PLA2G2A-20-GOOR | 20 (40 μL) | 200 μL |
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| MAPKAPK2-PLA2G2A-20-GOGO | 20 (40 μL) | 200 μL |
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| MAPKAPK2-PLA2G2A-20-GOGR | 20 (40 μL) | 200 μL |
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| MAPKAPK2-PLA2G2A-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAPKAPK2-PLA2G2A-20-GRRE | 20 (40 μL) | 200 μL |
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| MAPKAPK2-PLA2G2A-20-GROR | 20 (40 μL) | 200 μL |
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| MAPKAPK2-PLA2G2A-20-GRGO | 20 (40 μL) | 200 μL |
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| MAPKAPK2-PLA2G2A-20-GRGR | 20 (40 μL) | 200 μL |
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| MAPKAPK2-PLA2G2A-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAPKAPK2-PLA2G2A-20-AQRE | 20 (40 μL) | 200 μL |
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| MAPKAPK2-PLA2G2A-20-AQOR | 20 (40 μL) | 200 μL |
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| MAPKAPK2-PLA2G2A-20-AQGO | 20 (40 μL) | 200 μL |
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| MAPKAPK2-PLA2G2A-20-AQGR | 20 (40 μL) | 200 μL |
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| MAPKAPK2-PLA2G2A-20-AQAQ | 20 (40 μL) | 200 μL |
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PLA2G2A Gene Summary
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]
Gene Name: Phospholipase A2 Group IIA
Chromosome: CHR1: 20301923 -20306932
Locus: 1p36.13
MAPKAPK2 Gene Summary
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase-activated Protein Kinase 2
Chromosome: CHR1: 206858364 -206907630
Locus: 1q32.1
Gene Diseases
The MAPKAPK2 PLA2G2A Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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