MAPK9-DGKB Fusion FISH Probe
The MAPK9-DGKB Fusion FISH Probe is used to confirm a fusion of the MAPK9 and DGKB genes. The fusion of the MAPK9 and DGKB genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAPK9-DGKB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAPK9-DGKB-20-RERE | 20 (40 μL) | 200 μL |
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| MAPK9-DGKB-20-REOR | 20 (40 μL) | 200 μL |
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| MAPK9-DGKB-20-REGO | 20 (40 μL) | 200 μL |
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| MAPK9-DGKB-20-REGR | 20 (40 μL) | 200 μL |
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| MAPK9-DGKB-20-REAQ | 20 (40 μL) | 200 μL |
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| MAPK9-DGKB-20-ORRE | 20 (40 μL) | 200 μL |
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| MAPK9-DGKB-20-OROR | 20 (40 μL) | 200 μL |
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| MAPK9-DGKB-20-ORGO | 20 (40 μL) | 200 μL |
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| MAPK9-DGKB-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAPK9-DGKB-20-GORE | 20 (40 μL) | 200 μL |
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| MAPK9-DGKB-20-GOOR | 20 (40 μL) | 200 μL |
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| MAPK9-DGKB-20-GOGO | 20 (40 μL) | 200 μL |
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| MAPK9-DGKB-20-GOGR | 20 (40 μL) | 200 μL |
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| MAPK9-DGKB-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAPK9-DGKB-20-GRRE | 20 (40 μL) | 200 μL |
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| MAPK9-DGKB-20-GROR | 20 (40 μL) | 200 μL |
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| MAPK9-DGKB-20-GRGO | 20 (40 μL) | 200 μL |
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| MAPK9-DGKB-20-GRGR | 20 (40 μL) | 200 μL |
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| MAPK9-DGKB-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAPK9-DGKB-20-AQRE | 20 (40 μL) | 200 μL |
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| MAPK9-DGKB-20-AQOR | 20 (40 μL) | 200 μL |
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| MAPK9-DGKB-20-AQGO | 20 (40 μL) | 200 μL |
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| MAPK9-DGKB-20-AQGR | 20 (40 μL) | 200 μL |
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| MAPK9-DGKB-20-AQAQ | 20 (40 μL) | 200 μL |
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DGKB Gene Summary
Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]
Gene Name: Diacylglycerol Kinase Beta
Chromosome: CHR7: 14184673 -14881075
Locus: 7p21.2
MAPK9 Gene Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]
Gene Name: Mitogen-activated Protein Kinase 9
Chromosome: CHR5: 179660594 -179719071
Locus: 5q35.3
Gene Diseases
The MAPK9 DGKB Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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