MAPK8-KIRREL2 Fusion FISH Probe
The MAPK8-KIRREL2 Fusion FISH Probe is used to confirm a fusion of the MAPK8 and KIRREL2 genes. The fusion of the MAPK8 and KIRREL2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAPK8-KIRREL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAPK8-KIRREL2-20-RERE | 20 (40 μL) | 200 μL |
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| MAPK8-KIRREL2-20-REOR | 20 (40 μL) | 200 μL |
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| MAPK8-KIRREL2-20-REGO | 20 (40 μL) | 200 μL |
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| MAPK8-KIRREL2-20-REGR | 20 (40 μL) | 200 μL |
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| MAPK8-KIRREL2-20-REAQ | 20 (40 μL) | 200 μL |
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| MAPK8-KIRREL2-20-ORRE | 20 (40 μL) | 200 μL |
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| MAPK8-KIRREL2-20-OROR | 20 (40 μL) | 200 μL |
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| MAPK8-KIRREL2-20-ORGO | 20 (40 μL) | 200 μL |
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| MAPK8-KIRREL2-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAPK8-KIRREL2-20-GORE | 20 (40 μL) | 200 μL |
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| MAPK8-KIRREL2-20-GOOR | 20 (40 μL) | 200 μL |
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| MAPK8-KIRREL2-20-GOGO | 20 (40 μL) | 200 μL |
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| MAPK8-KIRREL2-20-GOGR | 20 (40 μL) | 200 μL |
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| MAPK8-KIRREL2-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAPK8-KIRREL2-20-GRRE | 20 (40 μL) | 200 μL |
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| MAPK8-KIRREL2-20-GROR | 20 (40 μL) | 200 μL |
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| MAPK8-KIRREL2-20-GRGO | 20 (40 μL) | 200 μL |
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| MAPK8-KIRREL2-20-GRGR | 20 (40 μL) | 200 μL |
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| MAPK8-KIRREL2-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAPK8-KIRREL2-20-AQRE | 20 (40 μL) | 200 μL |
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| MAPK8-KIRREL2-20-AQOR | 20 (40 μL) | 200 μL |
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| MAPK8-KIRREL2-20-AQGO | 20 (40 μL) | 200 μL |
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| MAPK8-KIRREL2-20-AQGR | 20 (40 μL) | 200 μL |
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| MAPK8-KIRREL2-20-AQAQ | 20 (40 μL) | 200 μL |
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MAPK8 Gene Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]
Gene Name: Mitogen-activated Protein Kinase 8
Chromosome: CHR10: 49609686 -49643183
Locus: 10q11.22
KIRREL2 Gene Summary
This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin (GeneID: 527362) are regulated by a bidirectional promoter. [provided by RefSeq, Jul 2016]
Gene Name: Kirre Like Nephrin Family Adhesion Molecule 2
Chromosome: CHR19: 36347809 -36358048
Locus: 19q13.12
Gene Diseases
The MAPK8 KIRREL2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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