MAPK14-SIN3A Fusion FISH Probe
The MAPK14-SIN3A Fusion FISH Probe is used to confirm a fusion of the MAPK14 and SIN3A genes. The fusion of the MAPK14 and SIN3A genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAPK14-SIN3A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAPK14-SIN3A-20-RERE | 20 (40 μL) | 200 μL |
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| MAPK14-SIN3A-20-REOR | 20 (40 μL) | 200 μL |
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| MAPK14-SIN3A-20-REGO | 20 (40 μL) | 200 μL |
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| MAPK14-SIN3A-20-REGR | 20 (40 μL) | 200 μL |
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| MAPK14-SIN3A-20-REAQ | 20 (40 μL) | 200 μL |
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| MAPK14-SIN3A-20-ORRE | 20 (40 μL) | 200 μL |
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| MAPK14-SIN3A-20-OROR | 20 (40 μL) | 200 μL |
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| MAPK14-SIN3A-20-ORGO | 20 (40 μL) | 200 μL |
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| MAPK14-SIN3A-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAPK14-SIN3A-20-GORE | 20 (40 μL) | 200 μL |
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| MAPK14-SIN3A-20-GOOR | 20 (40 μL) | 200 μL |
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| MAPK14-SIN3A-20-GOGO | 20 (40 μL) | 200 μL |
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| MAPK14-SIN3A-20-GOGR | 20 (40 μL) | 200 μL |
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| MAPK14-SIN3A-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAPK14-SIN3A-20-GRRE | 20 (40 μL) | 200 μL |
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| MAPK14-SIN3A-20-GROR | 20 (40 μL) | 200 μL |
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| MAPK14-SIN3A-20-GRGO | 20 (40 μL) | 200 μL |
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| MAPK14-SIN3A-20-GRGR | 20 (40 μL) | 200 μL |
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| MAPK14-SIN3A-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAPK14-SIN3A-20-AQRE | 20 (40 μL) | 200 μL |
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| MAPK14-SIN3A-20-AQOR | 20 (40 μL) | 200 μL |
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| MAPK14-SIN3A-20-AQGO | 20 (40 μL) | 200 μL |
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| MAPK14-SIN3A-20-AQGR | 20 (40 μL) | 200 μL |
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| MAPK14-SIN3A-20-AQAQ | 20 (40 μL) | 200 μL |
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MAPK14 Gene Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase 14
Chromosome: CHR6: 35995453 -36079013
Locus: 6p21.31
SIN3A Gene Summary
The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]
Gene Name: SIN3 Transcription Regulator Family Member A
Chromosome: CHR15: 75661719 -75748124
Locus: 15q24.2
Gene Diseases
The MAPK14 SIN3A Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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