MAPK1-ARHGEF7 Fusion FISH Probe
The MAPK1-ARHGEF7 Fusion FISH Probe is used to confirm a fusion of the MAPK1 and ARHGEF7 genes. The fusion of the MAPK1 and ARHGEF7 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAPK1-ARHGEF7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAPK1-ARHGEF7-20-RERE | 20 (40 μL) | 200 μL |
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| MAPK1-ARHGEF7-20-REOR | 20 (40 μL) | 200 μL |
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| MAPK1-ARHGEF7-20-REGO | 20 (40 μL) | 200 μL |
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| MAPK1-ARHGEF7-20-REGR | 20 (40 μL) | 200 μL |
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| MAPK1-ARHGEF7-20-REAQ | 20 (40 μL) | 200 μL |
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| MAPK1-ARHGEF7-20-ORRE | 20 (40 μL) | 200 μL |
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| MAPK1-ARHGEF7-20-OROR | 20 (40 μL) | 200 μL |
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| MAPK1-ARHGEF7-20-ORGO | 20 (40 μL) | 200 μL |
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| MAPK1-ARHGEF7-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAPK1-ARHGEF7-20-GORE | 20 (40 μL) | 200 μL |
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| MAPK1-ARHGEF7-20-GOOR | 20 (40 μL) | 200 μL |
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| MAPK1-ARHGEF7-20-GOGO | 20 (40 μL) | 200 μL |
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| MAPK1-ARHGEF7-20-GOGR | 20 (40 μL) | 200 μL |
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| MAPK1-ARHGEF7-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAPK1-ARHGEF7-20-GRRE | 20 (40 μL) | 200 μL |
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| MAPK1-ARHGEF7-20-GROR | 20 (40 μL) | 200 μL |
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| MAPK1-ARHGEF7-20-GRGO | 20 (40 μL) | 200 μL |
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| MAPK1-ARHGEF7-20-GRGR | 20 (40 μL) | 200 μL |
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| MAPK1-ARHGEF7-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAPK1-ARHGEF7-20-AQRE | 20 (40 μL) | 200 μL |
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| MAPK1-ARHGEF7-20-AQOR | 20 (40 μL) | 200 μL |
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| MAPK1-ARHGEF7-20-AQGO | 20 (40 μL) | 200 μL |
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| MAPK1-ARHGEF7-20-AQGR | 20 (40 μL) | 200 μL |
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| MAPK1-ARHGEF7-20-AQAQ | 20 (40 μL) | 200 μL |
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MAPK1 Gene Summary
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
Gene Name: Mitogen-activated Protein Kinase 1
Chromosome: CHR22: 22113946 -22221970
Locus: 22q11.22
ARHGEF7 Gene Summary
This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016]
Gene Name: Rho Guanine Nucleotide Exchange Factor 7
Chromosome: CHR13: 111767623 -111947542
Locus: 13q34
Gene Diseases
The MAPK1 ARHGEF7 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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