MAP7-NRG3 Fusion FISH Probe
The MAP7-NRG3 Fusion FISH Probe is used to confirm a fusion of the MAP7 and NRG3 genes. The fusion of the MAP7 and NRG3 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAP7-NRG3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAP7-NRG3-20-RERE | 20 (40 μL) | 200 μL |
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| MAP7-NRG3-20-REOR | 20 (40 μL) | 200 μL |
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| MAP7-NRG3-20-REGO | 20 (40 μL) | 200 μL |
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| MAP7-NRG3-20-REGR | 20 (40 μL) | 200 μL |
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| MAP7-NRG3-20-REAQ | 20 (40 μL) | 200 μL |
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| MAP7-NRG3-20-ORRE | 20 (40 μL) | 200 μL |
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| MAP7-NRG3-20-OROR | 20 (40 μL) | 200 μL |
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| MAP7-NRG3-20-ORGO | 20 (40 μL) | 200 μL |
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| MAP7-NRG3-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAP7-NRG3-20-GORE | 20 (40 μL) | 200 μL |
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| MAP7-NRG3-20-GOOR | 20 (40 μL) | 200 μL |
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| MAP7-NRG3-20-GOGO | 20 (40 μL) | 200 μL |
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| MAP7-NRG3-20-GOGR | 20 (40 μL) | 200 μL |
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| MAP7-NRG3-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAP7-NRG3-20-GRRE | 20 (40 μL) | 200 μL |
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| MAP7-NRG3-20-GROR | 20 (40 μL) | 200 μL |
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| MAP7-NRG3-20-GRGO | 20 (40 μL) | 200 μL |
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| MAP7-NRG3-20-GRGR | 20 (40 μL) | 200 μL |
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| MAP7-NRG3-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAP7-NRG3-20-AQRE | 20 (40 μL) | 200 μL |
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| MAP7-NRG3-20-AQOR | 20 (40 μL) | 200 μL |
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| MAP7-NRG3-20-AQGO | 20 (40 μL) | 200 μL |
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| MAP7-NRG3-20-AQGR | 20 (40 μL) | 200 μL |
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| MAP7-NRG3-20-AQAQ | 20 (40 μL) | 200 μL |
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MAP7 Gene Summary
The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Gene Name: Microtubule Associated Protein 7
Chromosome: CHR6: 136663418 -136871957
Locus: 6q23.3
NRG3 Gene Summary
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009]
Gene Name: Neuregulin 3
Chromosome: CHR10: 83635069 -84746935
Locus: 10q23.1
Gene Diseases
The MAP7 NRG3 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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