MAP4K5-NIN Fusion FISH Probe
The MAP4K5-NIN Fusion FISH Probe is used to confirm a fusion of the MAP4K5 and NIN genes. The fusion of the MAP4K5 and NIN genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAP4K5-NIN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAP4K5-NIN-20-RERE | 20 (40 μL) | 200 μL |
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| MAP4K5-NIN-20-REOR | 20 (40 μL) | 200 μL |
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| MAP4K5-NIN-20-REGO | 20 (40 μL) | 200 μL |
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| MAP4K5-NIN-20-REGR | 20 (40 μL) | 200 μL |
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| MAP4K5-NIN-20-REAQ | 20 (40 μL) | 200 μL |
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| MAP4K5-NIN-20-ORRE | 20 (40 μL) | 200 μL |
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| MAP4K5-NIN-20-OROR | 20 (40 μL) | 200 μL |
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| MAP4K5-NIN-20-ORGO | 20 (40 μL) | 200 μL |
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| MAP4K5-NIN-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAP4K5-NIN-20-GORE | 20 (40 μL) | 200 μL |
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| MAP4K5-NIN-20-GOOR | 20 (40 μL) | 200 μL |
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| MAP4K5-NIN-20-GOGO | 20 (40 μL) | 200 μL |
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| MAP4K5-NIN-20-GOGR | 20 (40 μL) | 200 μL |
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| MAP4K5-NIN-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAP4K5-NIN-20-GRRE | 20 (40 μL) | 200 μL |
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| MAP4K5-NIN-20-GROR | 20 (40 μL) | 200 μL |
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| MAP4K5-NIN-20-GRGO | 20 (40 μL) | 200 μL |
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| MAP4K5-NIN-20-GRGR | 20 (40 μL) | 200 μL |
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| MAP4K5-NIN-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAP4K5-NIN-20-AQRE | 20 (40 μL) | 200 μL |
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| MAP4K5-NIN-20-AQOR | 20 (40 μL) | 200 μL |
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| MAP4K5-NIN-20-AQGO | 20 (40 μL) | 200 μL |
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| MAP4K5-NIN-20-AQGR | 20 (40 μL) | 200 μL |
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| MAP4K5-NIN-20-AQAQ | 20 (40 μL) | 200 μL |
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MAP4K5 Gene Summary
This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase Kinase Kinase Kinase 5
Chromosome: CHR14: 50885210 -50999376
Locus: 14q22.1
NIN Gene Summary
This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Ninein
Chromosome: CHR14: 51186480 -51297839
Locus: 14q22.1
Gene Diseases
The MAP4K5 NIN Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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